2012

Pleines I, Hagedorn I, Gupta S, May F, Chakarova L, van Hengel J, Offermanns S, Krohne G, Kleinschnitz C, Brakebusch C, Nieswandt B (2012) Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood 119, 1054-1063 [Epub Nov 2011]

Szardien S, Nef HM, Voss S, Troidl C, Liebetrau C, Hoffmann J, Rauch M, Mayer K, Kimmich K, Rolf A, Rixe J, Troidl K, Kojonazarov B, Schermuly RT, Kostin S, Elsasser A, Hamm CW, Mollmann H (2012) Regression of cardiac hypertrophy by granulocyte colony-stimulating factor-stimulated interleukin-1beta synthesis. Eur Heart J 33: 595-605 [Epub Nov 2011]

Tappe-Theodor A, Constantin CE, Tegeder I, Lechner SG, Langeslag M, Lepcynzsky P, Wirotanseng RI, Kurejova M, Agarwal N, Nagy G, Todd A, Wettschureck N, Offermanns S, Kress M, Lewin GR, Kuner R (2012) Galpha(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization. Pain 153, 184-96 [epub Nov 2011]

Troidl K, Schaper W (2012) Arteriogenesis versus angiogenesis in peripheral artery disease. Diabetes Metab Res Rev 28 Suppl 1, 27-29

Weissmann N, Sydykov A, Kalwa H, Storch U, Fuchs B, Schnitzler MM, Brandes RP, Grimminger F, Meissner M, Freichel M, Offermanns S, Veit F, Pak O, Krause KH, Schermuly RT, Brewer AC, Schmidt HH, Seeger W, Shah AM, Gudermann T, Ghofrani HA, Dietrich A (2012) Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun 3, 649

Worzfeld T, Swiercz JM, Looso M, Straub BK, Sivaraj KK, Offermanns S (2012) ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis. J Clin Invest 122, 3296-2305

2011

Adjobo-Hermans MJ, Goedhart J, van Weeren L, Nijmeijer S, Manders EM, Offermanns S, Gadella TW, Jr. (2011) Real-time visualization of heterotrimeric G protein Gq activation in living cells. BMC Biol 9, 32

Albinsson S, Skoura A, Yu J, Dilorenzo A, Fernandez-Hernando C, Offermanns S, Miano JM, Sessa WC (2011) Smooth Muscle miRNAs Are Critical for Post-Natal Regulation of Blood Pressure and Vascular Function. PLoS One 6, e18869

Blad CC, Ahmed K, Ijzerman AP, Offermanns S (2011) Biological and pharmacological roles of HCA receptors. Adv Pharmacol 62, 219-250

Bondke Persson A, Buschmann EE, Lindhorst R, Langhoff R, Schulte KL, Troidl K, Buschmann I (2011) Therapeutic arteriogenesis in peripheral arterial disease: Combining intervention and passive training / Therapeutische Arteriogenese bei Peripherer Arterieller Verschlußkrankheit: Kombination von interventioneller Therapie und passivem Training. VASA - European Journal of Vascular Medicine [in press]

Hillmeister P, Gatzke N, Dulsner A, Bader M, Schadock I, Hoefer I, Hamann I, Infante-Duarte C, Jung G, Troidl K, Urban D, Stawowy P, Frentsch M, Li M, Nagorka S, Wang H, Shi Y, le Noble F, Buschmann I (2011) Arteriogenesis Is Modulated on Bradykinin Receptor Signaling. Circulation research (e-pub ahead of print)

Lob HE, Vinh A, Li L, Blinder Y, Offermanns S, Harrison DG (2011) Role of vascular extracellular superoxide dismutase in hypertension. Hypertension 58, 232-239

Lukasova M, Malaval C, Gille A, Kero J, Offermanns S (2011a) Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J Clin Invest 121, 1163-1173

Lukasova M, Hanson J, Tunaru S, Offermanns S (2011b) Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potential. Trends Pharmacol Sci 32, 700-707

Nemenoff RA, Horita H, Ostriker AC, Furgeson SB, Simpson PA, Vanputten V, Crossno J, Offermanns S, Weiser-Evans MC (2011) SDF-1{alpha} Induction in Mature Smooth Muscle Cells by Inactivation of PTEN Is a Critical Mediator of Exacerbated Injury-Induced Neointima Formation. Arterioscler Thromb Vasc Biol [epub]

Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, Ijzerman AP (2011) International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B). Pharmacol Rev 63, 269-290

Ogata N, Shinoda Y, Wettschureck N, Offermanns S, Takeda S, Nakamura K, Segre GV, Chung UI, Kawaguchi H (2011) G{alpha}q Signal in Osteoblasts Is Inhibitory to the Osteoanabolic Action of Parathyroid Hormone. J Biol Chem 286, 13733-13740

Planas-Paz L, Strilic B, Goedecke A, Breier G, Fassler R, Lammert E (2011) Mechanoinduction of lymph vessel expansion. EMBO J [epub]

Schierling W, Troidl K, Apfelbeck H, Troidl C, Kasprzak PM, Schaper W, Schmitz-Rixen T (2011) Cerebral Arteriogenesis is Enhanced by Pharmacological as Well as Fluid-Shear-Stress Activation of the Trpv4 Calcium Channel. Eur J Vasc Endovasc Surg 41, 589-596

2010

Ahmed, K., Tunaru, S., Tang, C., Müller, M., Gille, A., Sassmann, A., Hanson, J., and Offermanns, S. (2010) An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Cell Metab. 11, 311-19

Albinsson S, Suarez Y, Skoura A, Offermanns, S, Miano JM, Sessa WC. (2010) miRNAs are necessary for vascular smooth muscle growth, differentiation and function. Arterioscler Thromb Vasc Biol 30, 1118-1126

Casazza A, Finisguerra V, Capparuccia L, Camperi A, Swiercz JM, Rizzolio S, Rolny C, Christensen C, Bertotti A, Sarotto I, Risio M, Trusolino L, Weitz J, Schneider M, Mazzone M, Comoglio PM, Tamagnone L (2010) Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice. J Clin Invest 120, 2684-2698

Coulon P, Kanyshkova T, Broicher T, Munsch T, Wettschureck N, Seidenbecher T, Meuth SG, Offermanns S, Pape HC, Budde T (2010) Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling. Front Cell Neurosci 4, 132

Groneberg D, König P, Wirth A, Offermanns S, Koesling D, Friebe A. (2010) Smooth Muscle-Specific Deletion of Nitric Oxide-Sensitive Guanylyl Cyclase Is Sufficient to Induce Hypertension in Mice. Circulation 121, 401-409

Guilluy C, Brégeon J, Toumaniantz G, Rolli-Derkinderen M, Retailleau K, Loufrani L, Henrion D, Scalbert E, Bril A, Torres RM, Offermanns S, Pacaud P, Loirand G. (2010) The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. Nat. Med. 16, 183-190

Hanson J, Gille A, Zwykiel S, Lukasova M, Clausen BE, Ahmed K, Tunaru S, Wirth A, Offermanns S. (2010) Keratinocytes express GPR109A and mediate epidermal effects of nicotinic acid and mono-Methyl fumarate via COX-2-dependent prostanoid formation J. Clin. Invest. 120, 2910-2919

Hirschberg A, Deng S, Korostylev A, Paldy E, Costa MR, Worzfeld T, Vodrazka P, Wizenmann A, Götz M, Offermanns S, Kuner R. (2010) Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesis. Mol Cell Biol. 30, 764-80

Hoyer DP, Gronke S, Frank KF, Addicks K, Wettschureck N, Offermanns S, Erdmann E and Reuter H (2010) Diabetes-related defects in sarcoplasmic Ca(2+) release are prevented by inactivation of Galpha (11) and Galpha (q) in murine cardiomyocytes. Mol Cell Biochem 341, 235-244

Hoyer DP, Korkmaz Y, Gronke S, Addicks K, Wettschureck N, Offermanns S, Reuter H (2010) Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein Galpha11. Cardiovasc Diabetol 9, 93

Offermanns S (2010) Thrombozytäre Signaltransduktion. In: Hämostaseologie, Pötzsch B, Madlener K (Eds.) 2nd ed., Springer-Verlag, pp 81-88

Offermanns S (2010) In vivo Functions of Heterotrimeric G Proteins. In: Handbook of Cell Signalling (Vol. 2) Bradshaw RA, Dennis EA (Eds.) 2nd ed., Elsevier Inc., pp 1621-1627

Offermanns S (2010) G-Protein functions identified using genetic mouse models. In: G Protein-Coupled Receptors: Structure, Signalling, and Physiology, Siehler S, Milligan Graeme (Eds.), Cambridge University Press, pp 125-144

Sassmann A, Gier B, Gröne HJ, Drews G, Offermanns S, Wettschureck N. (2010) The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion J. Clin. Invest. 120, 2184-2193

Sassmann A, Offermanns S & Wettschureck N. (2010). Tamoxifen-inducible Cre-mediated recombination in adipocytes. Genesis, 48(10), 618-625.

Sayed A, Schierling W, Troidl K, Rüding I, Nelson K, Apfelbeck H, Benli I, Schaper W, Schmitz-Rixen T. (2010) Exercise linked ton transient increase in expression and activity of cation channels in newly formed hind-limb collaterals. EJVES 40, 81-87

Singh N, Thangaraju M, Prasad PD, Martin PM, Lambert NA, Boettger T, Offermanns S & Ganapathy V. (2010) Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases. J Biol Chem 285, 27601-27608

Strilic B, Eglinger J, Krieg M, Zeeb M, Axnick J, Babal P, Muller DJ, Lammert E (2010) Electrostatic cell-surface repulsion initiates lumen formation in developing blood vessels. Curr Biol 20(22), 2003-2009

Szereszewski JM, Pampillo M, Ahow MR, Offermanns S, Bhattacharya M & Babwah AV. (2010) GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Galpha(q/11) and beta-arrestin-dependent manner. PLoS One 5, e12964

Troidl K*, Tribulova S*, Cai WJ, Eitenmüller I, Wustrack H, Schierling W, Troidl C, Schaper W. (2010) Effects of endogenous NO and of DETA NONOate in Arteriogenesis. J Cardiovasc Pharmacol 55(2), 153-60

Troidl C, Nef H, Voss S, Schilp A, Kostin S, Troidl K, Szardien S, Rolf A, Schmitz-Rixen T, Schaper W, Hamm CW, Elsasser A, Mollmann H (2010) Calcium-dependent signalling is essential during collateral growth in the pig hind limb-ischemia model. J Mol Cell Cardiol 49(1), 142-151

Turm H, Grisaru-Granvosky S, Maoz M, Offermanns S, Bar-Shavit R (2010) DVL as a scaffold protein capturing classical GPCRs. Commun Integr Biol 3, 495-498

Turm H, Maoz M, Katz V, Yin YJ, Offermanns S, Bar-Shavit R. (2010) Protease activated receptor1 (PAR1) acts via  a novel G{alpha}13-dishevelled axis to stabilize {beta}-catenin levels. J Biol Chem 285, 15137-15148

Wang L, Guo DC, Cao J, Gong L, Kamm KE, Regalado E, Li L, Shete S, He WQ, Zhu MS, Offermanns S, Gilchrist D, Elefteriades J, Stull JT & Milewicz DM. (2010) Mutations in myosin light chain kinase cause familial aortic dissections. Am J Hum Genet 87, 701-707

Wirth A. (2010) Rho kinase and hypertension. Biochim Biophys Acta. May 13 [epub article]

Zeeb M, Strilic B, Lammert E (2010) Resolving cell-cell junctions: lumen formation in blood vessels. Curr Opin Cell Biol 22(5), 626-632

Zielonka M, Xia J, Friedel RH, Offermanns S, Worzfeld T. (2010) A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system. Exp Cell Res. 316, 2477-2486

2009

Ahmed K, Tunaru S, Langhans CD, Hanson J, Michalski CW, Kölker S, Jones PM, Okun JG, Offermanns S. (2009) Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis. J Biol Chem. 284, 21928-33

Ahmed K, Tunaru S, Offermanns S. (2009) GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors. Trends Pharmacol Sci. 30, 557-562

Gutkind JS, Offermanns S. (2009) A new G(q)-initiated MAPK signaling pathway in the heart. Dev. Cell  16, 163-164

Herroeder S, Reichardt P, Sassmann A, Zimmermann B, Jaeneke D, Hoeckner J, Hollmann MW, Fischer KD, Vogt S, Grosse R, Hogg N, Gunzer M, Offermanns S, Wettschureck N. (2009) Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility. Immunity 30, 708-720

Korhonen H, Fisslthaler B, Moers A, Wirth A, Habermehl D, Wieland T, Schütz G, Wettschureck N, Fleming I, Offermanns S. (2009) Anaphylactic shock depends on endothelial Gq/G11. J Exp Med, 206, 411-420

Plaisance EP, Lukasova M, Offermanns S, Zhang Y, Cao G, Judd RL. (2009) Niacin stimulates adiponectin secretion through the GPR109A receptor. Am J Physiol Endocrinol Metab.  296, E549-558

Schierling W*, Troidl K*, Troidl C, Schmitz-Rixen T, Schaper W, Eitenmüller IK. (2009) The Role of Angiogenic Growth Factors in Arteriogenesis. J Vasc Res 46(4), 365-374

Schierling W, Troidl K, Mueller C, Troidl C, Wustrack H, Bachmann G, Kasprzak PM, Schaper W, Schmitz-Rixen T. (2009) Increased intravascular flow rate triggers cerebral arteriogenesis. J Cereb Blood Flow Metab 29(4), 726-37

Sprossmann F, Pankert P, Sausbier U, Wirth A, Zhou XB, Madlung J, Zhao H, Bucurenciu I, Jakob A, Lamkemeyer T, Neuhuber W, Offermanns S, Shipston MJ, Korth M, Nordheim A, Ruth P, Sausbier M. (2009) Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder. FEBS J. 276, 1680-97

Swiercz JM, Worzfeld T, Offermanns S. (2009) Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex. Mol Cell Biol 29, 6321-34.

Troidl C*, Troidl K*, Schierling W, Cai WJ, Nef H, Möllmann H, Kostin S, Schimanski S, Hammer L, Elsässer A, Schmitz-Rixen T, Schaper W. (2009) Trpv4 induces collateral vessel growth during regeneration of the arterial circulation. J Cell Mol Med 13, 2613-21

Troidl C, Möllmann H, Nef H, Masseli F, Voss S, Szardien S, Willmer M, Rolf A, Rixe J, Troidl K, Kostin S, Hamm C, Elsässer A. (2009) Classically and alternatively activated macrophages contribute to tissue remodelling after myocardial infarction. J Cell Mol Med 13, 3485-96.

Troidl K, Rüding I, Cai WJ, Mücke Y, Grossekettler L, Piotrowska I, Schierling W, Volger OL, Horrevoets AJ, Schmitz-Rixen T, Schaper W, Troidl C. (2009) Actin-binding Rho activating protein (Abra) is essential for fluid shear stress-induced arteriogenesis. Arterioscler Thromb Vasc Biol 29, 2093-101

Vodrazka P, Korostylev A, Hirschberg A, Swiercz JM, Worzfeld T, Deng S, Fazzari P, Tamagnone L, Offermanns S, Kuner R. (2009) The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways. Eur J Neurosci 30, 1193-208

Worzfeld T and Offermanns S. (2009) G-Proteins. In: Schwab M. (ed). Encyclopedia of Cancer, 2nd edn. Springer, Berlin Heidelberg New York, 1189-1192 (ISBN: 978-3-540-47648-1)

Worzfeld T, Rauch P, Karram K, Trotter J, Kuner R, Offermanns S. (2009) Mice lacking Plexin-B3 display normal CNS morphology and behaviour. Mol Cell Neurosci 42, 372-81

Wustrack H, Schierling W, Troidl K, Troidl C, Schaper W, Schmitz-Rixen T. (2009) Stimulierung des Wachstums peripherer und zerebraler Kollateralarterien zur Erhöhung der intravasalen Flussrate im Tiermodell. Gefäßchirurgie 23, 24-30

2008

Broicher T, Wettschureck N, Munsch T, Coulon P, Meuth SG, Kanyshkova T, Seidenbecher T, Offermanns S, Pape HC, Budde T. (2008) Muscarinic ACh receptor-mediated control of thalamic activity via Gq/G11-family G-proteins. Pflugers Arch 456, 1049-1060

Gille A, Bodor ET, Ahmed K, Offermanns S. (2008) Nicotinic acid: Pharmacological effects and mechanisms of action. Annu Rev Pharmacol Toxicol 48, 79-106

Korostylev A, Worzfeld T, Deng S, Friedel RH, Swiercz JM, Vodrazka P, Maier V, Hirschberg A, Ohoka Y, Inagaki S, Offermanns S, Kuner R. (2008) Plexin-B2, but not plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo. Development 135, 3333-3345

Moers A, Nürnberg A, Goebbels S, Wettschureck N, Offermanns S. (2008) Gα12/Gα13-deficiency causes localized overmigration of neurons in the developing cerebral and cerebellar cortices. Mol Cell Biol 28, 1480-1488

Nürnberg A (2008): The roles of Gq and G12 families of G-proteins in the regulation of neurite morphology. Institute of Pharmacology. Submitted to the Medical Faculty of the Ruperto-Carola University of Heidelberg.
Ngai J, Methi T, Adressen KW, Levy FO, Trogersen KM, Vang T, Wettschureck N, Taskén K. (2008) The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway. Eur J Immunol 38, 3208-18.

Nürnberg A, Bräuer AU, Wettschureck N, Offermanns S. (2008) Antagonistic regulation of neurite morphology through Gq/G11 and G12/G13. J Biol Chem 283, 35526-35531

Offermanns S, Rosenthal W. (2008) Encyclopedia of molecular pharmacology, 2nd edn. Berlin ; New York: Springer.

Sato T, Kawamura Y, Asai R, Amano T, Uchijima Y, Dettlaff-Swiercz DA, Offermanns S, Kurihara Y, Kurihara H. (2008) Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development. Development 135, 755-765

Swiercz JM, Worzfeld T, Offermanns S. (2008) ErbB-2 and Met Reciprocally Regulate Cellular Signaling via Plexin-B1. J Biol Chem 283, 1893-1901

Wirth A, Benyó Z, Lukasova M, Leutgeb B, Wettschureck N, Gorbey S, Őrsy P, Horváth B, Maser-Gluth C, Greiner E, Lemmer B, Schütz G, Gutkind S, Offermanns S. (2008) G12/G13-LARG-mediated signalling in vascular smooth muscle is required for salt-induced hypertension. Nat Med 14, 64-68

Wirth A, Offermanns S. (2008) G-protein mediated signalling in salt-dependent hypertension. Drug Discov Today Dis Mech 5, e307-314

Worzfeld T (2008) Plexins. In: Encyclopedia of Molecular Pharmacology, Offermanns, Stefan; Rosenthal, Walter (Eds.) 2nd ed., XXVII, 1505 p. 487 (ISBN: 978-3-540-38921-7)

Worzfeld, T, Wettschureck, N, Offermanns S. (2008) G(12)/G(13)-mediated signalling in mammalian physiology and disease. Trends Pharmacol. Sci. 29, 582-589

2007

Ahmed K, Offermanns S. (2007) Nicotinic acid in lipid metabolism disorders. Pharm Unserer Zeit 36, 120-125

Deng S, Hirschberg A, Worzfeld T, Penachioni JY, Korostylev A, Swiercz JM, Vodrazka P, Mauti O, Stoeckli E, Tamagnone L, Offermanns S, Kuner R. (2007) Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo. J Neurosci 27, 6333-6347

Kero J, Ahmed K, Wettschureck N, Tunaru S, Wintermantel T, Greiner E, Schütz G, Offermanns S. (2007) Thyrocyte-specific Gq/G11-deficiency impairs thyroid function and prevents goiter development. J Clin Invest 117, 2399-2407

Müller MW, Giese NA, Swiercz JM, Ceyhan GO, Esposito I, Hinz U, Büchler P, Giese T, Büchler MW, Offermanns S, Friess H. (2007) Association of axon guidance factor Semaphorin 3A with poor outcome in pancreatic cancer. Int J Cancer 121, 2421-2433

Offermanns S (2007) Conditional mutagenesis of G-protein coupled receptors and G-proteins. In: Handb Exp Pharmacol 178, 491-509

Sassmann, A (2007):Charakterisierung der Stickstoffmonoxid-Synthase-Isoformen in kardiovaskulär relevanten Organen während der Entwicklung der spontanen Hypertonie bei Ratten. Universität zu Lübeck.

Tappe-Theodor A, Agarwal N, Katona I, Rubino T, Martini L, Swiercz J,Mackie K, Monyer H, Parolaro D, Whistler J, Kuner T, Kuner R. (2007) A molecular basis of analgesic tolerance to cannabinoids. J Neurosci 27(15), 4165-77

Wettschureck N, Lee E, Libutti SK, Offermanns S, Robey PG, Spiegel AM. (2007) Parathyroid-specific double knockout of Gq and G11 α-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+-sensing receptor. Mol Endocrinol 21, 274-280

Worzfeld T (2007): Expressions- und Funktionsanalyse der B-Plexine; Submitted to the Medical Faculty of the Ruperto-Carola University of Heidelberg.

2006

Benyo Z, Gille A, Bennett CL, Clausen BE, Offermanns S. (2006) Nicotinic Acid-induced flushing is mediated by activation of epidermal langerhans cells. Mol Pharmacol 70, 1844-1849

Eitenmüller I, Volger O, Kluge A, Troidl K, Barancik M, Cai WJ, Heil M, Pipp F, Fischer S, Horrevoets AJ, Schmitz-Rixen T, Schaper W. (2006) The range of adaptation by collateral vessels after femoral artery occlusion. Circ Res 99(6), 656-62.

Offermanns S. (2006) The nicotinic acid receptor GPR109A (HM74A/PUMA-G) as a new therapeutic target. Trends Pharmacol Sci 27, 384-390

Offermanns S. (2006) Activation of platelet function through G-protein-coupled receptors. Circ Res 99, 1293 – 1304

Rieken S, Herroeder S, Sassmann A, Wallenwein B, Moers A, Offermanns S, Wettschureck N. (2006) Lysophospholipids control integrin dependent adhesion in splenic B cells through Gi and G12/G13 family G-proteins, but not through Gq/G11. J Biol Chem 281, 36985-36992

Rieken S, Sassmann A, Herroeder S, Wallenwein B, Moers A, Offermanns S, Wettschureck N. (2006) G12/G13 family G proteins regulate marginal zone B cell maturation, migration, and polarization. J Immunol 177, 2985-2993

Wettschureck N, van der Stelt M, Tsubokawa H, Krestel H, Moers A, Petrosino S, Schütz G, di Marzo V, Offermanns S. (2006) Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation. Mol Cell Biol 26, 5888-5894

2005

Aktas B, Pozgajova M, Bergmeier W, Sunnarborg S, Offermanns S, Lee D, Wagner DD, Nieswandt B. (2005) Aspirin induces platelet receptor shedding via ADAM17 (TACE). J Biol Chem 280, 39716-39722

Benyo Z, Gille A, Kero J, Csiky M, Suchankova MC, Nusing RM, Moers A, Pfeffer K, Offermanns S. (2005) GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J Clin Invest 115, 3634-3640

Dettlaff-Swiercz DA, Wettschureck N, Moers A, Huber K, Offermanns S. (2005) Characteristic defects in neural crest cell specific Gαq/Gα11- and Gα12/Gα13-deficient mice. Dev Biol 282, 174-182

Goulimari P, Kitzing TM, Knieling H, Brandt DT, Offermanns S, Grosse R. (2005) Gα12/13 is essential for directed cell migration and localized Rho-Dia1 function. J Biol Chem 280, 42242-42251

Soulet C, Hechler B, Gratacap MP, Plantavid M, Offermanns S, Gachet C, Payrastre BA. (2005) A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation. J Thromb Haemost 3, 2296-2306

Taggart AK, Kero J, Gan X, Cai TQ, Cheng K, Ippolito M, Ren N, Kaplan R, Wu K, Wu TJ, Jin L, Liaw C, Chen R, Richman J, Connolly D, Offermanns S, Wright SD, Waters MG. (2005) D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J Biol Chem 280, 26649-26652

Tunaru S, Lattig J, Kero J, Krause G, Offermanns S. (2005) Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G). Mol Pharmacol 68, 1271-1280

Wettschureck N, Moers A, Wallenwein B, Maser-Gluth C, Offermanns S. (2005) Loss of Gq/11-family G-proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice. Mol Cell Biol 25, 1942-1948

Wettschureck N, Offermanns S. (2005) Mammalian G-proteins and their cell type specific functions. Physiol Rev 85, 1159-1204

Wieland T, Wettschureck N, Offermanns S (2005) Study of G proteins in cardiovascular research. In: Practical Methods in Cardiovascular Research, Dhein S, Mohr F, Delmar M (Eds.) Springer-Verlag, pp 759-783Wettschureck N, Offermanns S. (2005) Mammalian G-proteins and their cell type specific functions. Physiol Rev 85, 1159-1204

Wieland T, Wettschureck N, Offermanns S (2005) Study of G proteins in cardiovascular research. In: Practical Methods in Cardiovascular Research, Dhein S, Mohr F, Delmar M (Eds.) Springer-Verlag, pp 759-783

2004

Agarwal N, Offermanns S, Kuner R (2004) Conditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia. Genesis 38: 122-129

Grüner S, Prostredna M, Aktas B, Moers A, Schulte V, Krieg T, Offermanns S, Eckes B, Nieswandt B (2004) Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced a2b1 levels or concomitant aspirin therapy. Circulation 110: 2946-2951

Hartmann, J., Blum, R., Kovalchuk, Y., Adelsberger, H., Kuner, R., Durand, G.M., Miyata, M., Kano, M., Offermanns, S., and Konnerth, A. 2004. Distinct roles of Galpha(q) and Galpha11 for Purkinje cell signaling and motor behavior. J Neurosci 24:5119-5130..

Moers, A., Wettschureck, N., Gruner, S., Nieswandt, B., and Offermanns, S. 2004. Unresponsiveness of Platelets Lacking Both G{alpha}q and G{alpha}13: Implications for collagen-induced platelet activation. J Biol Chem 279:45354-45359.

Moers, A., Wettschureck, N., and Offermanns, S. 2004. G13-mediated signaling as a potential target for antiplatelet drugs. Drug News Perspect 17:493-498.

Nieswandt, B., and Offermanns, S. 2004. Pharmacology of platelet adhesion and aggregation. In Handbook of experimental Pharmacology. J. Behrens, and J. Nelson, editors. Berlin, Heidelberg, New York: Springer. 437-471.

Offermanns S (2004) Antiplatelet drugs. In: Encyclopedic Reference of Molecular Pharmacology, Offermanns S, Rosenthal W (Eds.), Springer-Verlag, pp 106-109 

Offermanns S (2004) G₁₂/G₁₃ family. In: Encyclopedia of Biological Chemistry Vol. 2, Lennarz WJ, Lane MD (Eds.), pp 158-161

Offermanns S (2004) G-Protein-Mediated Signalling Pathways. In: Handbook of Experimental Pharmacology Vol. 159,

Offermanns S, Hein L (Eds.), Springer-Verlag, pp 165-192

Offermanns S (2004) In vivo functions of heterotrimeric G-proteins. In: Handbook of Cell Signalling, Bradshaw RA, Dennis EA (Eds.), Academic Press, Vol. 2, pp 581-585

Swiercz, J.M., Kuner, R., and Offermanns, S. 2004. Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2. J Cell Biol 165:869-880.

Wettschureck, N., Moers, A., Hamalainen, T., Lemberger, T., Schutz, G., and Offermanns, S. 2004. Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice. Mol Cell Biol 24:8048-8054.

Wettschureck, N., Moers, A., and Offermanns, S. 2004. Mouse models to study G-protein-mediated signaling. Pharmacol Ther 101:75-89.

Worzfeld, T., Puschel, A.W., Offermanns, S., and Kuner, R. 2004. Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: an anatomical basis for morphogenetic effects of Sema4D during development. Eur J Neurosci 19:2622-2632.

2003

Kuijpers, M.J., Schulte, V., Bergmeier, W., Lindhout, T., Brakebusch, C., Offermanns, S., Fassler, R., Heemskerk, J.W., and Nieswandt, B. 2003. Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo. Faseb J 17:685-687.

Marinissen, M.J., Servitja, J.M., Offermanns, S., Simon, M.I., and Gutkind, J.S. 2003. Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation. J Biol Chem 278:46814-46825.

Moers, A., Nieswandt, B., Massberg, S., Wettschureck, N., Gruner, S., Konrad, I., Schulte, V., Aktas, B., Gratacap, M.P., Simon, M.I., et al. 2003. G13 is an essential mediator of platelet activation in hemostasis and thrombosis. Nat Med 9:1418-1422.

Offermanns, S. 2003. G-proteins as transducers in transmembrane signalling. Prog Biophys Mol Biol 83:101-130.

Taggart, A.K., Kero, J., Gan, X., Cai, T.Q., Cheng, K., Ippolito, M., Ren, N., Kaplan, R., Wu, K., Wu, T.J., et al. 2005. (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J Biol Chem 280:26649-26652.

Tunaru, S., Kero, J., Schaub, A., Wufka, C., Blaukat, A., Pfeffer, K., and Offermanns, S. 2003. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat Med 9:352-355.

Vogt, S., Grosse, R., Schultz, G., and Offermanns, S. 2003. Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11. J Biol Chem 278:28743-28749.

2002

Gu JL, Müller S, Mancino V, Offermanns S, Simon MI (2002) Interaction of Ga₁₂ with Ga₁₃ and Ga_q signaling pathways. Proc Natl Acad Sci USA 99: 9352-9357

Krause M, Offermanns S, Stocker M, Pedarzani P (2002) Specific roles of Ga_q and Ga₁₁ in the cholinergic and glutamatergic modulation of potassium currents and excitability of hippocampal neurons. J Neurosci 22: 666-673

Kuner R, Swiercz J, Zywietz A, Tappe A, Offermanns S (2002) Characterization of the expression of PDZ-RhoGEF, LARG and Ga₁₂/Ga₁₃ proteins in the murine nervous system. Eur J Neurosci 16: 2333-2341

Miura M, Watanabe M, Offermanns S, Simon MI, Kano M (2002) Group I mGluR signalling via Gaq secures the induction of long-term potentiation in the hippocampal area CA1. J Neurosci 22: 8379-8390

Nieswandt B, Schulte V, Zywietz A, Gratacap MP, Offermanns S (2002) Costimulation of G_i- and G₁₂/G₁₃-mediated signaling pathways induces integrin aIIbb3 activation in platelets. J Biol Chem 277: 39493-39498

Swiercz J, Kuner R, Behrens J, Offermanns S (2002) Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron 35: 51-63

Wettschureck N, Offermanns S (2002) Physiological and pathological roles of the Rho/Rho-kinase mediated pathway. J Mol Med 80: 629-638

2001

Gratacap MP, Payrastre B, Nieswandt B, Offermanns S (2001) Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Biol Chem 276: 47906-47913

Kleppisch T, Voigt V, Allmann R, Offermanns S (2001) Ga_q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region. J Neurosci 21: 4943-4948

Nieswandt B, Bergmeier W, Eckly A, Schulte V, Ohlmann P, Cazenave JP, Zirngibl H, Offermanns S, Gachet C (2001) Evidence for cross-talk between GPVI and G_i coupled receptors during collagen-induced platelet aggregation. Blood 97: 3829-3835

Offermanns S (2001) Der G_q/G₁₁-vermittelte zellulärte Signalweg und seine Bedeutung für kardiale Erkrankungen. Z Kardiol 90: 601-606

Offermanns S (2001) G Proteins. In: Cancer Research Encyclopedia, Schwab, M. (Ed.), Springer-Verlag, pp 367-372

Offermanns S (2001) In vivo functions of heterotrimeric G-proteins: Studies in Ga-deficient mice. Oncogene 20: 1635-1642

Offermanns S, Negulescu P, Hu YH, Simon MI (2001) Conditionally expressed Ga₁₅ couples to endogenous receptors in GH₃ cells. Naunyn Schmiedeberg’s Arch Pharmacol 364: 140-148

Postma FR, Jalink K, Hengeveld T, Offermanns S, Moolenaar WH (2001) Ga₁₃ mediates activation of a depolarizing chloride current that accompanies RhoA activation in both neuronal and non-neuronal cells. Curr Biol 11: 121-124

Wettschureck N, Rütten H, Zywietz A, Gehring D, Wilkie T, Chen J, Chien KR, Offermanns S (2001) Cardiomyocyte-restricted Ga_q/Ga₁₁-deficiency prevents pressure overload induced myocardial hypertrophy. Nat Med 7: 1236-1240

Zywietz A, Gohla A, Schmelz M, Schultz G, Offermanns S (2001) Pleiotropic effects of Pasteurella multocida toxin are mediated by G_q-dependent and -independent mechanisms. Involvement of G_q but not G₁₁. J Biol Chem 276: 3840-3845

2000

Blaukat A, Barac A, Cross MJ, Offermanns S, Dikic I (2000) G protein-coupled receptor-mediated MAP kinase activation through cooperation of Ga_q and Ga_i signals. Mol Cell Biol 20: 6837-6848

Gohla A, Schultz G, Offermanns S (2000) A role for G₁₂/G₁₃ in agonist-induced vascular smooth muscle cell contraction. Circ Res 87: 221-227

Haley JE, Delmas P, Offermanns S, Abogadie FC, Simon MI, Buckley NJ, Brown DA (2000) Muscarinic inhibition of calcium current and M-current in Ga_q-deficient mice. J Neurosci 20: 3973-3979

Hashimoto K, Watanabe M, Kurihara H, Offermanns S, Jiang H, Wu Y, Jun K, Shin HS, Inoue Y, Wu D, Simon MI, Kano M (2000) Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Ga_q and phospholipase Cb4 Prog Brain Res 124: 31-48

Klemke M, Pasolli HA, Kehlenbach RH, Offermanns S, Schultz G, Huttner WB (2000) Characterization of XLas. II. Signal transduction properties. J Biol Chem 275: 33633-33640

Offermanns S (2000) Mammalian G-protein function in vivo: New insights through altered gene expression. Rev Physiol Biochem Pharmacol 140: 63-133

Offermanns S (2000) The role of heterotrimeric G-proteins in platelet activation. Biol Chem 381: 389-396

Ohlmann P, Eckly A, Freund M, Cazenave JP, Offermanns S, Gachet C (2000) Partial platelet aggregation without shape change and potentiation of collagen induced platelet aggregation by ADP in the absence of Ga_q. Blood 96: 2134-213 

Ponimaskin E, Behn H, Adarichev V, Voyno-Yasenetskaya TA, Offermanns S, Schmidt MFG (2000) Acylation of Ga₁₃ is important for its interaction with thrombin receptor, transforming activity and stress fiber formation. FEBS Lett 478: 173-177

Tsubokawa H, Offermanns S, Simon M, Kano M (2000) Calcium-dependent persistent facilitation of spike backpropagation in the CA1 pyramidal neurons. J Neurosci 20: 4878-4884