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Alexander SP, et al. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. (2021) Br J Pharmacol. 178 Suppl 1:S27-S156

Allanki S, Strilic B, Scheinberger L, Onderwater YL, Marks A, Günther S, Preussner J, Kikhi K, Looso M, Stainier DYR, Reischauer S. (2021) Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration. Sci Adv. 7, eabg6497

Berillo O, Coelho SC, Mahjoub N, Offermanns S, Paradis P, Schiffrin EL. (2021) Aldosterone contributes to hypertension in male mice inducibly overexpressing human endothelin-1 in endothelium. J Hypertens. 39, 1908-1917

Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I. (2021) Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function. Circulation. 143, 935-948

Demirel E, Arnold C, Garg J, Jäger MA, Sticht C, Li R, Kuk H, Wettschureck N, Hecker M, Korff T. (2021) RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells. Cells 10, 1748

Dubrall D, Pflock R, Kosinska J, Schmid M, Bleich M, Himmerkus N, Offermanns S, Schwaninger M, Sachs B. (2021) Do dimethyl fumarate and nicotinic acid elicit common, potentially HCA2 -mediated adverse reactions? A combined epidemiological-experimental approach. Br J Clin Pharmacol. 87, 3813-3824

Grunddal KV, Tonack S, Egerod KL, Thompson JJ, Petersen N, Engelstoft MS, Vagne C, Keime C, Gradwohl G, Offermanns S, Schwartz TW. (2021) Adhesion Receptor Adgrg2/Gpr64 Is In The Gi-Tract Selectively Expressed In Mature Intestinal Tuft Cells. Mol Metab. 51, 101231

Jin YJ, Chennupati R, Li R, Liang G, Wang S, Iring A, Graumann J, Wettschureck N, Offermanns S. (2021) Protein kinase N2 mediates flow-induced eNOS activation and vascular tone regulation. J Clin Invest. 131, e145734

Jiang C, Javed A, Kaiser L, Nava MM, Xu R, Brandt DT, Zhao D, Mayer B, Fernández-Baldovinos J, Zhou L, Höß C, Sawmynaden K, Oleksy A, Matthews D, Weinstein LS, Hahn H, Gröne HJ, Graumann PL, Niessen CM, Offermanns S, Wickström SA, Worzfeld T. (2021) Mechanochemical control of epidermal stem cell divisions by B-plexins. Nat Commun. 12, 1308

Le Mercier A, Bonnavion R, Yu W, Alnouri MW, Ramas S, Zhang Y, Jäger Y, Roquid KA, Jeong HW, Sivaraj KK, Cho H, Chen X, Strilic B, Sijmonsma T, Ralf Adams R, Schroeder T, Rieger MA, Offermanns S. (2021) GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis. Proc Natl Acad Sci USA. 118, e2021596118

Lee J, Jin YJ, Lee MS, Kim YM, Lee H. (2021) Macrophage inhibitory cytokine-1 promotes angiogenesis by eliciting the GFRAL-mediated endothelial cell signaling. J Cell Physiol. 236, 4008-4023

Lopez M, Malacarne PF, Gajos-Draus  A, Ding X, Daiber A, Lundberg JO, Offermanns S, Brandes RP, Flávia Rezende F. (2021) Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases. Br J Pharmacol. 178, 1495-1506

Molnár PJ, Dér B, Borsodi K, Balla H, Borbás Z, Molnár K, Ruisanchez É, Kenessey I, Horváth A, Keszthelyi A, Majoros A, Nyirády P, Offermanns S, Benyó Z. (2021) Isoprostanes evoke contraction of the murine and human detrusor muscle via activation of the thromboxane prostanoid TP receptor and Rho-kinase. Am J Physiol Renal Physiol. 320, F537-F547

Müller M, Ringer K, Hub F, Kamm N, Worzfeld T, Jacob R. (2021) TTL-Expression Modulates Epithelial Morphogenesis. Front Cell Dev Biol. 9, 635723

Sieland J, Niederer D, Engeroff T, Vogt L, Troidl C, Schmitz-Rixen T, Banzer W, Troidl K. (2021) Effects of single bouts of different endurance exercises with different intensities on microRNA biomarkers with and without blood flow restriction: a three-arm, randomized crossover trial. Eur J Appl Physiol. 2021 Aug 25. [online ahead of print]

Simonetti M, Paldy E, Njoo C, Bali KK, Worzfeld T, Pitzer C, Kuner T, Offermanns S, Mauceri D, Kuner R. (2021) The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology. Mol Psychiatry. 26, 1376-1398

Teinturier R, Luo Y, Decaussin-Petrucci M, Vlaeminck-Guillem V, Vacherot F, Firlej V, Bonnavion R, Abou Ziki R, Gherardi S, Goddard I, Gadot N, Bertolino P, Le Romancer M, Zhang CX. (2021) Men1 disruption in Nkx3.1-deficient mice results in ARlow/CD44+ microinvasive carcinoma development with the dysregulated AR pathway. Oncogene 40, 1118-1127

Wang L, Rice M, Swist S, Kubin T, Wu F, Wang S, Kraut S, Weissmann N, Böttger T, Wheeler M, Schneider A, Braun T. (2021) BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State. Circulation 143, 1394-1410

Ward SM, Hwang SJ, Yan W, Offermanns S, Sanders KM. (2021) Intrinsic pacemaker activity and propulsive forces provided by the MYOSALPINX are necessary for egg and embryo transport in the oviduct. Biol Reprod. 2021 Nov 8: ioab209 [online ahead of print]

Xu L, Wettschureck N, Bai Y, Yuan Z, Wang S. (2021) Myofibroblast YAP/TAZ is dispensable for liver fibrosis in mice. J Hepatol. 75, 238-241


Bae H, Hong KY, Lee CK, Jang C, Lee SJ, Choe K, Offermanns S, He Y, Lee HJ, Koh GY. (2020) Angiopoietin-2-integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance. Nat Commun. 11, 2980

Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I. (2020) Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function. Circulation. 2020 Dec 14. [online ahead of print]

Blankenbach KV, Claas RF, Aster NJ, Spohner AK, Trautmann S, Ferreirós N, Black JL, Tesmer JJG, Offermanns S, Wieland T, Meyer Zu Heringdorf D. (2020) Dissecting Gq/11-Mediated Plasma Membrane Translocation of Sphingosine Kinase-1. Cells. 9, E2201

Carvalho J, Chennupati R, Li R, Günther S, Kaur H, Zhao W, Tonack S, Kurz M, Mößlein N, Bünemann M, Offermanns S, Wettschureck N. (2020) Orphan G-Protein-Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling. Circulation. 141, 1168-1183

Cetinkaya A, Berge B, Sen-Hild B, Troidl K, Gajawada P, Kubin N, Valeske K, Schranz D, Akintürk H, Schönburg M, Kubin T, Choi YH, Richter M. (2020) Radixin Relocalization and Nonmuscle α-Actinin Expression Are Features of Remodeling Cardiomyocytes in Adult Patients with Dilated Cardiomyopathy. Dis Markers. 2020, 9356738

Götze AM, Schubert C, Jung G, Dörr O, Liebetrau C, Hamm CW, Schmitz-Rixen T, Troidl C, Troidl K. (2020) IL10 Alters Peri-Collateral Macrophage Polarization and Hind-Limb Reperfusion in Mice after Femoral Artery Ligation. Int J Mol Sci. 21(8)

Horimatsu T, Blomkalns AL, Ogbi M, Moses M, Kim D, Patel S, Gilreath N, Reid L, Benson TW, Pye J, Ahmadieh S, Thompson A, Robbins N, Mann A, Edgell A, Benjamin S, Stansfield BK, Huo Y, Fulton DJ, Agarwal G, Singh N, Offermanns S, Weintraub NL, Kim HW. (2020) Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide. Cardiovasc Res. 116, 2226-2238

Isobe J, Maeda S, Obata Y, Iizuka K, Nakamura Y, Fujimura Y, Kimizuka T, Hattori K, Kim YG, Morita T, Kimura I, Offermanns S, Adachi T, Nakao A, Kiyono H, Takahashi D, Hase K. (2020) Commensal-bacteria-derived butyrate promotes the T-cell-independent IgA response in the colon. Int Immunol. 32, 243-258

Khatib-Massalha E, Bhattacharya S, Massalha H, Biram A, Golan K, Kollet O, Kumari A, Avemaria F, Petrovich-Kopitman E, Gur-Cohen S, Itkin T, Brandenburger I, Spiegel A, Shulman Z, Gerhart-Hines Z, Itzkovitz S, Gunzer M, Offermanns S, Alon R, Ariel A, Lapidot T. (2020) Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling. Nat Commun. 11, 3547

Kwon HB, Mackie DI, Bonnavion R, Mercier AL, Helker CSM, Son T, Guenter S, Serafin DS, Kim KW, Offermanns S, Caron KM, Stainier DYR. (2020) The Orphan G-Protein Coupled Receptor 182 Is a Negative Regulator of Definitive Hematopoiesis through Leukotriene B4 Signaling. ACS Pharmacol Transl Sci. 3, 676-689

Li M, Nishio SY, Naruse C, Riddell M, Sapski S, Katsuno T, Hikita T, Mizapourshafiyi F, Smith FM, Cooper LT, Lee MG, Asano M, Boettger T, Krueger M, Wietelmann A, Graumann J, Day BW, Boyd AW, Offermanns S, Kitajiri SI, Usami SI, Nakayama M. (2020) Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome. Nat Commun. 11, 1343

Nakayama A, Albarrán-Juárez J, Liang G, Roquid KA, Iring A, Tonack S, Chen M, Müller OJ, Weinstein LS, Offermanns S. (2020) Disturbed flow-induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis. JCI Insight. 5, 140485

Perniss A, Liu S, Boonen B, Keshavarz M, Ruppert AL, Timm T, Pfeil U, Soultanova A, Kusumakshi S, Delventhal L, Aydin Ö, Pyrski M, Deckmann K, Hain T, Schmidt N, Ewers C, Günther A, Lochnit G, Chubanov V, Gudermann T, Oberwinkler J, Klein J, Mikoshiba K, Leinders-Zufall T, Offermanns S, Schütz B, Boehm U, Zufall F, Bufe B, Kummer W. (2020) Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides. Immunity. 52, 683-699.e11

Simmons JD, Peterson GJ, Campo M, Lohmiller J, Skerrett SJ, Tunaru S, Offermanns S, Sherman DR, Hawn TR. (2020) Nicotinamide Limits Replication of Mycobacterium tuberculosis and Bacille Calmette-Guérin Within Macrophages. J Infect Dis. 221, 989-999

Sreenivasan K, Ianni A, Künne C, Strilic B, Günther S, Perdiguero E, Krüger M, Spuler S, Offermanns S, Gómez-Del Arco P, Redondo JM, Munoz-Canoves P, Kim J, Braun T. (2020) Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles. Cell Rep. 19, 107652

Stanicek L, Lozano-Vidal N, Bink DI, Hooglugt A, Yao W, Wittig I, van Rijssel J, van Buul JD, van Bergen A, Klems A, Ramms AS, Le Noble F, Hofmann P, Szulcek R, Wang S, Offermanns S, Ercanoglu MS, Kwon HB, Stainier D, Huveneers S, Kurian L, Dimmeler S, Boon RA. (2020) Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function. Commun Biol. 3, 265

Troidl K, Schubert C, Vlacil AK, Chennupati R, Koch S, Schütt J, Oberoi R, Schaper W, Schmitz-Rixen T, Schieffer B, Grote K. (2020) The Lipopeptide MALP-2 Promotes Collateral Growth. Cells. 9(4)

Troidl K, Hammerschick T, Albarran-Juarez J, Jung G, Schierling W, Tonack S, Krüger M, Matuschke B, Troidl C, Schaper W, Schmitz-Rixen T, Preissner KT, Fischer S. (2020) Shear Stress-Induced miR-143-3p in Collateral Arteries Contributes to Outward Vessel Growth by Targeting Collagen V-α2. Arterioscler Thromb Vasc Biol. 40, e126-e137

van den Bos E, Ambrosy B, Horsthemke M, Walbaum S, Bachg AC, Wettschureck N, Innamorati G, Wilkie TM, Hanley PJ. (2020) Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor-mediated chemotaxis. J Biol Chem. 295, 7726-7742

Vogel J, Niederer D, Jung G, Troidl K. (2020) Exercise-Induced Vascular Adaptations under Artificially Versus Pathologically Reduced Blood Flow: A Focus Review with Special Emphasis on Arteriogenesis. Cells. 9(2)

Wang L, Wang S, Shi Y, Li R, Günther S, Yuan Z, Liu E, Offermanns S (2020) YAP and TAZ protect against white adipocyte cell death during obesity. Nat Commun. 11, 5455

Wang L, Chennupati R, Jin YJ, Li R, Wang S, Günther S, Offermanns S. (2020) YAP/TAZ Are Required to Suppress Osteogenic Differentiation of Vascular Smooth Muscle Cells. iScience. 23, 101860

Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, Honoré E, Offermanns S. (2020) Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. Nat Commun. 11, 2303

Wenzel J, Hansen CE, Bettoni C, Vogt MA, Lembrich B, Natsagdorj R, Huber G, Brands J, Schmidt K, Assmann JC, Stölting I, Saar K, Sedlacik J, Fiehler J, Ludewig P, Wegmann M, Feller N, Richter M, Müller-Fielitz H, Walther T, König GM, Kostenis E, Raasch W, Hübner N, Gass P, Offermanns S, de Wit C, Wagner CA, Schwaninger M. (2020) Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice. Proc Natl Acad Sci U S A. 117, 1753-1761


Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors. Br J Pharmacol. 176 Suppl 1, S21-S141

Bresler A, Vogel J, Niederer D, Gray D, Schmitz-Rixen T, Troidl K (2019) Development of an Exercise Training Protocol to Investigate Arteriogenesis in a Murine Model of Peripheral Artery Disease. Int J Mol Sci. 20(16).

Chennupati R, Wirth A, Favre J, Li R, Bonnavion R, Jin YJ, Wietelmann A, Schweda F, Wettschureck N, Henrion D, Offermanns S. (2019) Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance. Elife 8.

de Castro Abrantes H, Briquet M, Schmuziger C, Restivo L, Puyal J, Rosenberg N, Rocher AB, Offermanns S, Chatton JY (2019). The lactate receptor HCAR1 modulates neuronal network activity through the activation of Gα and Gβɣ subunits. J Neurosci. 39, 4422-4433

Dér B, Molnár PJ, Ruisanchez É, Őrsy P, Kerék M, Faragó B, Nyirády P, Offermanns S, Benyó Z (2019) NK2 receptor mediated detrusor muscle contraction involves Gq/11-dependent activation of voltage-dependent calcium channels and the RhoA-Rho kinase pathway. Am J Physiol Renal Physiol. 317, F1154-F1163

Elsemüller AK, Tomalla V, Gärtner U2, Troidl K, Jeratsch S, Graumann J, Baal N, Hackstein H, Lasch M, Deindl E, Preissner KT, Fischer S. (2019) Characterization of mast cell-derived rRNA-containing microvesicles and their inflammatory impact on endothelial cells. FASEB J. 33, 5457-5467

Erdogmus S, Storch U, Danner L, Becker J, Winter M, Ziegler N, Wirth A, Offermanns S, Hoffmann C, Gudermann T, Mederos Y Schnitzler M. (2019) Helix 8 is the essential structural motif of mechanosensitive GPCRs. Nat Commun. 10, 5784

Finkernagel F, Reinartz S, Schuldner M, Malz A, Jansen JM, Wagner U, Worzfeld T, Graumann J, von Strandmann EP, Müller R. (2019) Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment. Theranostics. 9, 6601-6617

Graumann J, Finkernagel F, Reinartz S, Stief T, Brödje D, Renz H, Jansen JM, Wagner U, Worzfeld T, Pogge von Strandmann E, Müller R. (2019) Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma. Front Oncol. 9, 1150

Helker CSM, Mullapudi ST, Mueller LM, Preussner J, Tunaru S, Skog O, Kwon HB, Kreuder F, Lancman JJ, Bonnavion R, Dong PDS, Looso M, Offermanns S, Korsgren O, Spagnoli FM, Stainier DYR (2019) Whole organism small molecule screen identifies novel regulators of pancreatic endocrine development. Development 146(14).

Horimatsu T, Blomkalns AL, Ogbi M, Moses M, Kim D, Patel S, Gilreath N, Reid L, Benson TW, Pye J, Ahmadieh S, Thompson A, Robbins N, Mann A, Edgell A, Benjamin S, Stansfield BK, Huo Y, Fulton DJ, Agarwal G, Singh N, Offermanns S, Weintraub NL, Kim HW. (2019) Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide Cardiovasc Res. 2019 Nov 9. [Epub ahead of print]

Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S (2019) Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. J Clin Invest. 130:2775-2791

Isobe J, Maeda S, Obata Y, Iizuka K, Nakamura Y, Fujimura Y, Kimizuka T, Hattori K, Kim YG, Morita T, Kimura I, Offermanns S, Adachi T, Nakao A, Kiyono H, Takahashi D, Hase K. Commensal-bacteria-derived butyrate promotes the T cell-independent IgA response in the colon. Int Immunol. 2019 Dec 20. [Epub ahead of print]

Kaur H, Carvalho J, Looso M, Singh P, Chennupati R, Preussner J, Günther S, Albarrán-Juárez J, Tischner D, Classen S, Offermanns S, Wettschureck N. (2019) Author Correction: Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system. Nat Commun. 10, 1448

Lasch M, Kleinert EC, Meister S, Kumaraswami K, Buchheim JI, Grantzow T, Lautz T, Salpisti S, Fischer S, Troidl K, Fleming I, Randi AM, Sperandio M, Preissner KT, Deindl E. (2019) Extracellular RNA released due to shear stress controls natural bypass growth by mediating mechanotransduction in mice. Blood 134, 1469-1479

Niaudet C, Petkova M, Jung B, Lu S, Laviña B, Offermanns S, Brakebusch C, Betsholtz C (2019) Adgrf5 contributes to patterning of the endothelial deep layer in retina. Angiogenesis [Epub ahead of print]

Panta CR, Ruisanchez É, Móré D, Dancs PT, Balogh A, Fülöp Á, Kerék M, Proia RL, Offermanns S, Tigyi GJ, Benyó Z. (2019) Sphingosine-1-Phosphate Enhances α1-Adrenergic Vasoconstriction via S1P2-G12/13-ROCK Mediated Signaling. Int J Mol Sci. 20(24)

Reinartz S, Lieber S, Pesek J, Brandt DT, Asafova A, Finkernagel F, Watzer B, Nockher WA, Nist A, Stiewe T, Jansen JM, Wagner U, Konzer A, Graumann J, Grosse R, Worzfeld T, Müller-Brüsselbach S, Müller R. (2019) Cell type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment. Mol. Oncol.13, 185-201

Sakaguchi T, Takefuji M, Wettschureck N, Hamaguchi T, Amano M, Kato K, Tsuda T, Eguchi S, Ishihama S, Mori Y, Yura Y, Yoshida T, Unno K, Okumura T, Ishii H, Shimizu Y, Bando YK, Ohashi K, Ouchi N, Enomoto A, Offermanns S, Kaibuchi K, Murohara T. (2019) Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of its Interaction with Actin. Circulation. 140, 1737-1752

Simmons JD, Peterson GJ, Campo M, Lohmiller J, Skerrett SJ, Tunaru S, Offermanns S, Sherman DR, Hawn TR. (2019) Nicotinamide limits replication of Mycobacterium tuberculosis and BCG within macrophages. J Infect Dis. [Epub ahead of print]

Schürmann C, Dienst FL, Pálfi K, Vasconez AE, Oo JA, Wang S, Buchmann GK, Offermanns S, van de Sluis B, Leisegang MS, Günther S, Humbert PO, Lee E, Zhu J, Weigert A, Mathoor P, Wittig I, Kruse C, Brandes RP. (2019) The polarity protein Scrib limits atherosclerosis development in mice. Cardiovasc Res. 115, 1963-1974

Simonetti M, Paldy E, Njoo C, Bali KK, Worzfeld T, Pitzer C, Kuner T, Offermanns S, Mauceri D, Kuner R (2019) The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology. Mol Psychiatry. [Epub ahead of print]

Tisch N, Freire-Valls A, Yerbes R, Paredes I, La Porta S, Wang X, Martín-Pérez R, Castro L, Wong WW, Coultas L, Strilic B, Gröne HJ, Hielscher T, Mogler C, Adams R, Heiduschka P, Claesson-Welsh L, Mazzone M, López-Rivas A, Schmidt T, Augustin HG, Ruiz de Almodovar C (2019) Caspase-8 modulates physiological and pathological angiogenesis during retina development. J Clin Invest. 129(, 5092-5107

Vogel J, Niederer D, Engeroff T, Vogt L, Troidl C, Schmitz-Rixen T, Banzer W, Troidl K (2019) Effects on the Profile of Circulating miRNAs after Single Bouts of Resistance Training with and without Blood Flow Restriction-A Three-Arm, Randomized Crossover Trial. Int J Mol Sci. 20(13).

Wettschureck N, Strilic B, Offermanns S (2019) Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation. Physiol Rev. 99, 1467-1525

Yang L, Joseph S, Sun T, Hoffmann J, Thevissen S, Offermanns S, Strilic B. (2019) TAK1 regulates endothelial cell necroptosis and tumor metastasis. Cell Death Differ. 26, 1987-1997

Yin W, Kim HT, Wang S, Gunawan F, Li R, Buettner C, Grohmann B, Sengle G, Sinner D, Offermanns S, Stainier DYR. (2019) Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis. Eur Respir J. 53(3).


Albarrán-Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, Wettschureck N, Althoff TF, Offermanns S. (2018) Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med. 215, 2655-2672

Chen Y, Ouyang X, Hoque R, Garcia-Martinez I, Yousaf MN, Tonack S, Offermanns S, Dubuquoy L, Louvet A, Mathurin P, Massey V, Schnabl B, Bataller RA, Mehal WZ. (2018) B-hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway. J Hepatol. 69, 687-696

Coelho SC, Berillo O, Caillon A, Ouerd S, Fraulob-Aquino JC, Barhoumi T, Offermanns S, Paradis P, Schiffrin EL. (2018) Three-Month Endothelial Human Endothelin-1 Overexpression Causes Blood Pressure Elevation and Vascular and Kidney Injury. Hypertension. 71, 208-216

Gauvrit S, Villasenor A, Strilic B, Kitchen P, Collins MM, Marín-Juez R, Guenther S, Maischein HM, Fukuda N, Canham MA, Brickman JM, Bogue CW, Jayaraman PS, Stainier DYR. (2018) HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development. Nat Commun. 9, 2704

Kim HT, Yin W, Jin YJ, Panza P, Gunawan F, Grohmann B, Buettner C, Sokol AM, Preussner J, Guenther S, Kostin S, Ruppert C, Bhagwat AM, Ma X, Graumann J, Looso M, Guenther A, Adelstein RS, Offermanns S, Stainier DYR. (2018) Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease. Nat Commun. 9, 4600

Lautz T, Lasch M, Borgolte J, Troidl K, Pagel JI, Caballero-Martinez A, Kleinert EC, Walzog B, Deindl E. (2018) Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3. EBioMedicine. 27, 237-246

Lieber S, Reinartz S, Raifer H, Finkernagel F, Dreyer T, Bronger H, Jansen JM, Wagner U, Worzfeld T, Müller R, Huber M. (2018) Prognosis of ovarian cancer is associated with effector memory CD8+ T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells. Oncoimmunology. 7, e1424672

Mende F, Hundahl C, Plouffe B, Skov LJ, Sivertsen B, Madsen AN, Lückmann M, Diep TA, Offermanns S, Frimurer TM, Bouvier M, Holst B. (2018) Translating biased signaling in the ghrelin receptor system into differential in vivo functions. Proc Natl Acad Sci U S A. 115, E10255-E10264

Rödiger M, Werno MW, Wilhelmi I, Baumeier C, Hesse D, Wettschureck N, Offermanns S, Song K, Krauß M, Schürmann A. (2018) Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes. Mol Metab. 8, 167-179

Tunaru S, Bonnavion R, Brandenburger I, Preussner J, Thomas D, Scholich K, Offermanns S. (2018) 20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1. Nat Commun. 9, 177

Vardjan N, Chowdhury HH, Horvat A, Velebit J, Malnar M, Muhič M, Kreft M, Krivec ŠG, Bobnar ST, Miš K, Pirkmajer S, Offermanns S, Henriksen G, Storm-Mathisen J, Bergersen LH, Zorec R. (2018) Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP. Front Mol Neurosci. 11, 148

Villahoz S, Yunes-Leites PS, Méndez-Barbero N, Urso K, Bonzon-Kulichenko E, Ortega S, Nistal JF, Vazquez J, Offermanns S, Redondo JM, Campanero MR. (2018) Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture. Nat Commun. 9, 4795

Wannick M, Assmann JC, Vielhauer JF, Offermanns S, Zillikens D, Sadik CD, Schwaninger M. (2018) The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation. Front Immunol. 14, 1890

Worzfeld T, Finkernagel F, Reinartz S, Konzer A, Adhikary T, Nist A, Stiewe T, Wagner U, Looso M, Graumann J, Müller R. (2018) Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment. Mol Cell Proteomics. 17, 270-289

Yin W, Kim HT, Wang S, Gunawan F, Wang L, Kishimoto K, Zhong H, Roman D, Preussner J, Guenther S, Graef V, Buettner C, Grohmann B, Looso M, Morimoto M, Mardon G, Offermanns S, Stainier DYR. (2018) The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun. 9, 2815


Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2017) THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 174 Suppl 1, S1-S16

Braun T, Offermanns S, Stainier DYR, Seeger W. (2017) The Max Planck Institute for Heart and Lung Research Curiosity-Driven Basic Research to Fight Cardio-Pulmonary Diseases. Circ Res. 120,1386-1389

Breuer J, Herich S, Schneider-Hohendorf T, Chasan AI, Wettschureck N, Gross CC, Loser K, Zarbock A, Roth J, Klotz L, Wiendl H, Schwab N. (2017) Dual action by fumaric acid esters synergistically reduces adhesion to human endothelium. Mult Scler. 2017 Oct 1, 1352458517735189 [Epub ahead of print]

Brown K, Filuta A, Ludwig MG, Seuwen K, Jaros J, Vidal S, Arora K, Naren AP, Kandasamy K, Parthasarathi K, Offermanns S, Mason RJ, Miller WE, Whitsett JA, Bridges JP. (2017) Epithelial Gpr116 regulates pulmonary alveolar homeostasis via Gq/11 signaling. JCI Insight. 2 [e-collection]

Dancs PT, Ruisanchez É, Balogh A, Panta CR, Miklós Z, Nüsing RM, Aoki J, Chun J, Offermanns S, Tigyi G, Benyó Z. (2017) LPA1 receptor-mediated thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle contraction. FASEB J. 31, 1547-1555

Doçi CL, Mikelis CM, Callejas-Valera JL, Hansen KK, Molinolo AA, Inoue A, Offermanns S, Gutkind JS. (2017) Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes. PLoS One. 12, e0173692

Hohmann SW, Angioni C, Tunaru S, Lee S, Woolf CJ, Offermanns S, Geisslinger G, Scholich K, Sisignano M. (2017) The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity. Sci Rep. 7, 446

Idris-Khodja N, Ouerd S, Trindade M, Gornitsky J, Rehman A, Barhoumi T, Offermanns S, Gonzalez FJ, Neves MF, Paradis P, Schiffrin EL. (2017) Vascular smooth muscle cell peroxisome proliferator-activated receptor γ protects against endothelin-1-induced oxidative stress and inflammation. J Hypertens. 35, 1390-1401

Kaur H, Carvalho J, Looso M, Singh P, Chennupati R, Preussner J, Günther S, Albarrán-Juárez J, Tischner D, Classen S, Offermanns S, Wettschureck N. (2017) Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system. Nat Commun. 8,15700

Kespohl M, Vachharajani N, Luu M, Harb H, Pautz S, Wolff S, Sillner N, Walker A, Schmitt-Kopplin P, Boettger T, Renz H, Offermanns S, Steinhoff U, Visekruna A. (2017) The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells. Front Immunol. 8, 1036

Kroetsch JT, Levy AS, Zhang H, Aschar-Sobbi R, Lidington D, Offermanns S, Nedospasov SA, Backx PH, Heximer SP, Bolz SS. (2017) Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure. Nat Commun. 8, 14805

Liao M, Zhou J, Wang F, Ali YH, Chan KL, Zou F, Offermanns S, Jiang Z, Jiang Z. (2017) An X-linked Myh11-CreERT2 mouse line resulting from Y to X chromosome-translocation of the Cre allele. Genesis. 55 [epub]

Liu S, Lu S, Xu R, Atzberger A, Günther S, Wettschureck N, Offermanns S. (2017) Members of Bitter Taste Receptor Cluster Tas2r143/Tas2r135/Tas2r126 Are Expressed in the Epithelium of Murine Airways and Other Non-gustatory Tissues. Front Physiol. 8, 849

Lu S, Liu S, Wietelmann A, Kojonazarov B, Atzberger A, Tang C, Schermuly RT, Gröne HJ, Offermanns S. (2017) Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4). PLoS One. 12, e0183166

Meyer CW, Ootsuka Y, Romanovsky AA. (2017) Body Temperature Measurements for Metabolic Phenotyping in Mice. Front Physiol. 8, 520

Morland C, Andersson KA, Haugen ØP, Hadzic A, Kleppa L, Gille A, Rinholm JE, Palibrk V, Diget EH, Kennedy LH, Stølen T, Hennestad E, Moldestad O, Cai Y, Puchades M, Offermanns S, Vervaeke K, Bjørås M, Wisløff U, Storm-Mathisen J, Bergersen LH. (2017) Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nat Commun. 8, 15557

Müller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V, Benzin A, Wenzel J, Kalies K, Mittag J, Heuer H, Offermanns S, Schwaninger M. (2017) Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis. Nat Commun. 8, 484

Offermanns S. (2017) Hydroxy-Carboxylic Acid Receptor Actions in Metabolism. Trends Endocrinol Metab. 28, 227-236

Paldy E, Simonetti M, Worzfeld T, Bali KK, Vicuña L, Offermanns S, Kuner R. (2017) Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain. Nat Commun. 8, 176

Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, Hsi TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G. (2017) Regeneration of fat cells from myofibroblasts during wound healing. Science. 355, 748-752

Ruiz de Azua I, Mancini G, Srivastava RK, Rey AA, Cardinal P, Tedesco L, Zingaretti CM, Sassmann A, Quarta C, Schwitter C, Conrad A, Wettschureck N, Vemuri VK, Makriyannis A, Hartwig J, Mendez-Lago M, Bindila L, Monory K, Giordano A, Cinti S, Marsicano G, Offermanns S, Nisoli E, Pagotto U, Cota D, Lutz B. (2017) Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages. J Clin Invest. 127, 4148-4162

Schmitz K, Brunkhorst R, de Bruin N, Mayer CA, Häussler A, Ferreiros N, Schiffmann S, Parnham MJ, Tunaru S, Chun J, Offermanns S, Foerch C, Scholich K, Vogt J, Wicker S, Lötsch J, Geisslinger G, Tegeder I. (2017) Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis. Acta Neuropathol Commun. 5, 42

Strilic B, Offermanns S. (2017) Intravascular Survival and Extravasation of Tumor Cells. Cancer Cell. 32, 282-293

Sun T, Yang L, Kaur H, Pestel J, Looso M, Nolte H, Krasel C, Heil D, Krishnan RK, Santoni MJ, Borg JP, Bünemann M, Offermanns S, Swiercz JM, Worzfeld T. (2017) A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib. J Cell Biol. 216, 199-215

Tang C, Offermanns S. (2017) FFA2 and FFA3 in Metabolic Regulation. Handb Exp Pharmacol. 236, 205-220

Tischner D, Grimm M, Kaur H, Staudenraus D, Carvalho J, Looso M, Günther S, Wanke F, Moos S, Siller N, Breuer J, Schwab N, Zipp F, Waisman A, Kurschus FC, Offermanns S, Wettschureck N. (2017) Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation. JCI Insight. 2 [Epub ahead of print]

Tsuda T, Takefuji M, Wettschureck N, Kotani K, Morimoto R, Okumura T, Kaur H, Eguchi S, Sakaguchi T, Ishihama S, Kikuchi R, Unno K, Matsushita K, Ishikawa S, Offermanns S, Murohara T. (2017) Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction. J Exp Med. 214, 1877-1888

Wang Q, Yue WWS, Jiang Z, Xue T, Kang SH, Bergles DE, Mikoshiba K, Offermanns S, Yau KW. (2017) Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle. Curr Biol. 27, 1791-1800

Wanke F, Moos S, Croxford AL, Heinen AP, Gräf S, Kalt B, Tischner D, Zhang J, Christen I, Bruttger J, Yogev N, Tang Y, Zayoud M, Israel N, Karram K, Reißig S, Lacher SM, Reichhold C, Mufazalov IA, Ben-Nun A, Kuhlmann T, Wettschureck N, Sailer AW, Rajewsky K, Casola S, Waisman A, Kurschus FC. (2017) EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells. Cell Rep. 18, 1270-1284

Worzfeld T, Swiercz JM. (2017) Characterizing ErbB-2-Mediated Tyrosine Phosphorylation and Activation of Plexins. Methods Mol Biol. 1493, 129-146

Worzfeld T, Pogge von Strandmann E, Huber M, Adhikary T, Wagner U, Reinartz S, Müller R. (2017) The Unique Molecular and Cellular Microenvironment of Ovarian Cancer. Front Oncol. 7, 24

Zahedi F, Nazari-Jahantigh M, Zhou Z, Subramanian P, Wei Y, Grommes J, Offermanns S, Steffens S, Weber C, Schober A. (2017) Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. Cell Mol Life Sci. 74, 359-372

Zinn S, Sisignano M, Kern K, Pierre S, Tunaru S, Jordan H, Suo J, Treutlein EM, Angioni C, Ferreiros N, Leffler A, DeBruin N, Offermanns S, Geisslinger G, Scholich K. (2017) The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons. J Biol Chem. 292, 6123-6134


Albarrán-Juárez J, Kaur H, Grimm M, Offermanns S, Wettschureck N. (2016) Lineage tracing of cells involved in atherosclerosis. Atherosclerosis 251, 445-53

Chillo O, Kleinert EC, Lautz T, Lasch M, Pagel JI, Heun Y, Troidl K, Fischer S, Caballero-Martinez A, Mauer A, Kurz AR, Assmann G, Rehberg M, Kanse SM, Nieswandt B, Walzog B, Reichel CA, Mannell H, Preissner KT, Deindl E. (2016) Perivascular Mast Cells Govern Shear Stress-Induced Arteriogenesis by Orchestrating Leukocyte Function. Cell Rep.16, 2197-207

Errea A, Cayet D, Marchetti P, Tang C, Kluza J, Offermanns S, Sirard JC, Rumbo M. (2016) Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner. PLoS One. 11, e0163694

Gong H, An S, Sassmann A, Liu M, Mastej V, Mittal M, Zhang W, Hong Z, Offermanns S, Rehman J, Malik AB. (2016) PAR1 Scaffolds TGFβRII to Downregulate TGF-β Signaling and Activate ESC Differentiation to Endothelial Cells. Stem Cell Reports. 7, 1050-1058

Grimm M, Tischner D, Troidl K, Albarrán Juárez J, Sivaraj KK, Ferreirós Bouzas N, Geisslinger G, Binder CJ, Wettschureck N. (2016) S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population. Arterioscler Thromb Vasc Biol. 36, 37-48

Grunddal KV, Ratner CF, Svendsen B, Sommer F, Engelstoft MS, Madsen AN, Pedersen J, Nøhr MK, Egerod KL, Nawrocki AR, Kowalski T, Howard AD, Poulsen SS, Offermanns S, Bäckhed F, Holst JJ, Holst B, Schwartz TW. (2016) Neurotensin Is Co-Expressed, Co-Released And Acts Together With Glp-1 And Pyy In Enteroendocrine Control Of Metabolism. Endocrinology 157, 176-194

Hansen RK, Mund A, Poulsen SL, Sandoval M, Klement K, Tsouroula K, Tollenaere MA, Räschle M, Soria R, Offermanns S, Worzfeld T, Grosse R, Brandt DT, Rozell B, Mann M, Cole F, Soutoglou E, Goodarzi AA, Daniel JA, Mailand N, Bekker-Jensen S. (2016) SCAI promotes DNA double-strand break repair in distinct chromosomal contexts. Nat Cell Biol. 18, 1357-1366

Healy JA, Nugent A, Rempel RE, Moffitt AB, Davis NS, Jiang X, Shingleton JR, Zhang J, Love C, Datta J, McKinney ME, Tzeng TJ, Wettschureck N, Offermanns S, Walzer KA, Chi JT, Rasheed SA, Casey PJ, Lossos IS, Dave SS. (2016) GNA13 loss in germinal center B cells leads to impaired apoptosis and GC B cell persistence and promotes lymphoma in vivo. Blood 127, 2723-31

Illison J, Tian L, McClafferty H, Werno M, Chamberlain LH, Leiss V, Sassmann A, Offermanns S, Ruth P, Shipston MJ, Lukowski R. (2016) Obesogenic and Diabetogenic Effects of High-Calorie Nutrition Require Adipocyte BK Channels. Diabetes. 65, 3621-3635

John AE, Wilson MR, Habgood A, Porte J, Tatler AL, Stavrou A, Miele G, Jolly L, Knox AJ, Takata M, Offermanns S, Jenkins RG. (2016) Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema. Sci Signal. 9, ra104

Kaur H, Takefuji M, Ngai CY, Carvalho J, Bayer J, Wietelmann A, Poetsch A, Hoelper S, Conway SJ, Möllmann H, Looso M, Troidl C, Offermanns S, Wettschureck N (2016) Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice. Circ Res. 118: 1906-17

Kleinert E, Langenmayer MC, Reichart B, Kindermann J, Griemert B, Blutke A, Troidl K, Mayr T, Grantzow T, Noyan F, Abicht JM, Fischer S, Preissner KT, Wanke R, Deindl E, Guethoff S. (2016) Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation. J Am Heart Assoc., 5 [epub]

Kohli S, Ranjan S, Hoffmann J, Kashif M, Daniel EA, Al-Dabet MM, Bock F, Nazir S, Huebner H, Mertens PR, Fischer KD, Zenclussen AC, Offermanns S, Aharon A, Brenner B, Shahzad K, Ruebner M, Isermann B. (2016) Maternal extracellular vesicles and platelets promote preeclampsia through inflammasome activation in embryonic trophoblast. Blood. 128, 2153-2164

Kovacs L, Han W, Rafikov R, Bagi Z, Offermanns S, Saido TC, Black SM, Su Y (2016) Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol. 54, 384-393

Kwon HB, Wang S, Helker CS, Rasouli SJ, Maischein HM, Offermanns S, Herzog W, Stainier DY (2016) In vivo modulation of endothelial polarization by Apelin receptor signalling. Nat Commun. 7, 11805

Lasch M, Caballero-Martinez A, Troidl K, Schloegl I, Lautz T, Deindl E. (2016) Arginase inhibition attenuates arteriogenesis and interferes with M2 macrophage accumulation. Lab Invest. 96, 830-838

Li YQ, Shrestha Y, Pandey M, Chen M, Kablan A, Gavrilova O, Offermanns S, Weinstein LS (2016). Gq/11α and Gsα mediate distinct physiological responses to central melanocortins. J Clin Invest. 26, 40-49

Paradis P, Coelho SC, Ouerd S, Fraulob-Aquino JC, Offermanns S, Schiffrin EL. (2016) OS 21-06 THREE-MONTH EXPOSURE TO ENDOTHELIN-1 OVEREXPRESSION INCREASES BLOOD PRESSURE AND CAUSES SMALL ARTERY INJURY. J Hypertens. 34 Suppl 1, e236

Retailleau K, Arhatte M, Demolombe S, Peyronnet R, Baudrie V, Jodar M, Bourreau J, Henrion D, Offermanns S, Nakamura F, Feng Y, Patel A, Duprat F, Honoré E (2016) Arterial Myogenic Activation through Smooth Muscle Filamin A. Cell Rep. 14, 2050-2058

Retailleau K, Arhatte M, Demolombe S, Jodar M, Baudrie V, Offermanns S, Feng Y, Patel A, Honoré E, Duprat F (2016) Smooth muscle filamin A is a major determinant of conduit artery structure and function at the adult stage. Pflugers Arch. 468, 1151-60

Sassmann-Schweda A, Singh P, Tang C, Wietelmann A, Wettschureck N, Offermanns S (2016) Increased apoptosis and browning of TAK1-deficient adipocytes protects agains obesity. JCI Insight 1: e81175

Sauvé M, Hui SK, Dinh DD, Foltz WD, Momen A, Nedospasov SA, Offermanns S, Husain M, Kroetsch JT, Lidington D, Bolz SS (2016) Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes. Diabetes. 65: 1916-28

Schreier B, Hünerberg M, Rabe S, Mildenberger S, Bethmann D, Heise C, Sibilia M, Offermanns S, Gekle M (2016). Consequences of postnatal vascular smooth muscle EGF-receptor deltion on acute angiotensin II action. Clin Sci (Lond). 130, 19-33

Strilic B, Yang L, Albarrán-Juárez J, Wachsmuth L, Han K, Müller UC, Pasparakis M, Offermanns S. (2016) Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature. 536, 215-218

Tunaru S, Chennupati R, Nüsing RM, Offermanns S. (2016) Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor. PLoS One. 11, e0163633

Wang SP, Chennupati R, Iring A, Kaur H, Wettschureck N, Offermanns S. (2016) Endothelial Piezo1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest. 126, 4527-4536

Wirth A, Wang S, Takefuji M, Tang C, Althoff TF, Schweda F, Wettschureck N, Offermanns S. (2016). Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling. Cardiovasc Res. 109, 131-140

Worzfeld T, Schwaninger M. (2016) Apicobasal polarity of brain endothelial cells. J Cereb Blood Flow Metab. 36, 340-362

Xia J, Worzfeld T (2016) Semaphorins and Plexins in Kidney Disease. Nephron 132, 93-100


Althoff TF, Offermanns S (2015). G-protein-mediated signaling in vascular smooth muscle cells - implications for vascular disease. J Mol Med (Berl). 93, 973-981

Babwah AV, Navarro VM, Ahow M, Pampillo M, Nash C, Fayazi M, Calder M, Elbert A, Urbanski HF, Wettschureck N, Offermanns S, Carroll RS, Bhattacharya M, Tobet SA, Kaiser UB (2015). GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion. J Neurosci. 35, 12903-12916

Krishnan RK, Nolte H, Sun T, Kaur H, Sreenivasan K, Looso M, Offermanns S, Krüger M, Swiercz JM. (2015) Quantitative analysis of the TNF-α-induced phosphoproteome reveals AEG-1/MTDH/LYRIC as an IKKβ substrate. Nat. Commun. 6, 6658

Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S, Maruya M, Ian McKenzie C, Hijikata A, Wong C, Binge L, Thorburn AN, Chevalier N, Ang C, Marino E, Robert R, Offermanns S, Teixeira MM, Moore RJ, Flavell RA, Fagarasan S, Mackay CR. (2015) Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat. Commun. 6, 6734

Masuda M, Miyazaki-Anzai S, Keenan AL, Okamura K, Kendrick J, Chonchol M, Offermanns S, Ntambi JM, Kuro-O M, Miyazaki M (2015). Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity. J Clin Invest. 125, 4544-4558

Mikelis CM, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, Masedunskas A, Weigert R, Chavakis T, Adams RH, Offermanns S, Mochizuki N, Zheng Y, Gutkind JS. (2015) RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nat. Commun. 6, 6725

Nohr MK, Egerod KL, Christiansen SH, Gille A, Offermanns S, Schwartz TW, Moller M (2015). Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia. Neuroscience 290C, 126-137

Nussbaum C, Bannenberg S, Keul P, Gräler MH, Gonçalves-de-Albuquerque CF, Korhonen H, von Wnuck Lipinski K, Heusch G, de Castro Faria Neto HC, Rohwedder I, Göthert JR, Prasad VP, Haufe G, Lange-Sperandio B, Offermanns S, Sperandio M, Levkau B. (2015) Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nat. Commun. 6, 6416

Offermanns S, Schwaninger M. (2015) Nutritional or pharmacological activation of HCA2 ameliorates neuroinflammation. Trends Mol. Med. 21, 245-255

Rautureau Y, Coelho SC, Fraulob-Aquino JC, Huo KG, Rehman A, Offermanns S, Paradis P, Schiffrin EL (2015). Inducible human endothelin-1 overexpression in endothelium raises blood pressure via endothelin type A receptors. Hypertension 66, 347-355

Retailleau K, Duprat F, Arhatte M, Ranade SS, Peyronnet R, Martins JR, Jodar M, Moro C, Offermanns S, Feng Y, Demolombe S, Patel A, Honoré E (2015). Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling. Cell Rep. 13: 1161-1171

Rotllan N, Wanschel AC, Fernández-Hernando A, Salerno AG, Offermanns S, Sessa WC, Fernández-Hernando C. (2015) Genetic Evidence Supports a Major Role for Akt1 in VSMCs During Atherogenesis. Circ. Res. 116,1744-1752

Sivaraj KK, Li R, Albarran-Juarez J, Wang S, Tischner D, Grimm M, Swiercz JM, Offermanns S, Wettschureck N (2015). Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis. Cardiovasc Res. 108, 171-180

Sumida T, Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, Komuro I (2015). Complement C1q-induced activation of beta-catenin signalling causes hypertensive arterial remodelling. Nat. Commun. 6, 6241

Szekeres M, Nádasy GL, Turu G, Soltész-Katona E, Benyó Z, Offermanns S, Ruisanchez É, Szabó E, Takáts Z, Bátkai S, Tóth ZE, Hunyady L. (2015) Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension. Mol. Cell Endocrinol. 403, 46-56

Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S (2015). Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes. Nat. Med. 21, 173-177

Tang H, Chen J, Fraidenburg DR, Song S, Sysol JR, Drennan AR, Offermanns S, Ye RD, Bonini MG, Minshall RD, Garcia JG, Machado RF, Makino A, Yuan JX. (2015) Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 308, L208-20

Xia J, Swiercz JM, Bañón-Rodríguez I, Sun T, Frederico G, Matkovic I, Franz T, Brakebusch CH, Kumanogoh A, Friedel RH, Martín-Belmonte F, Gröne HJ, Offermanns S, Worzfeld T. Semaphorin-plexin signaling controls mitotic spindle orientation during epithelial morphogenesis and repair. Dev. Cell 33, 299-313

Wang S, Iring A, Strilic B, Albarrán Juárez J, Kaur H, Troidl K, Tonack S, Burbiel JC, Müller CE, Fleming I, Lundberg JO, Wettschureck N, Offermanns S (2015). P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction. J. Clin. Invest. 125, 3077-3086

Williams CM, Harper MT, Goggs R, Walsh TG, Offermanns S, Poole AW (2015). Leukemia-Associated RhoGEF (LARG) is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice. J Thromb Haemost. 13, 2102-2107

Worzfeld T, Schwaninger M (2015). Apicobasal polarity of brain endothelial cells. J Cereb Blood Flow Metab.  [Epub ahead of print]

Yagi K, Lidington D, Wan H, Fares JC, Meissner A, Sumiyoshi M, Ai J, Foltz WD, Nedospasov SA, Offermanns S, Nagahiro S, Macdonald RL, Bolz SS (2015). Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage. Stroke 46, 2260-2270


André G, Sandoval JE, Retailleau K, Loufrani L, Toumaniantz G, Offermanns S, Rolli-Derkinderen M, Loirand G, Sauzeau V. (2014) Smooth Muscle Specific Rac1 Deficiency Induces Hypertension by Preventing p116RIP3-Dependent RhoA Inhibition. J. Am. Heart Assoc. 3, e000852

Arnold C, Feldner A, Pfisterer L, Hödebeck M, Troidl K, Genové G, Wieland T, Hecker M, Korff T. (2014) RGS5 promotes arterial growth during arteriogenesis. EMBO Mol Med.6,1075-89

Chagin AS, Vuppalapati KK, Kobayashi T, Guo J, Hirai T, Chen M, Offermanns S, Weinstein LS, Kronenberg HM. (2014) G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes. Nat Commun 30, 3673

Chang PV, Hao L, Offermanns S, Medzhitov R. (2014) The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A 111, 2247-52

Chen H, Assmann JC, Krenz A, Rahman M, Grimm M, Karsten CM, Köhl J, Offermanns S, Wettschureck N, Schwaninger M. (2014) Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE. J Clin Invest. 124, 2188-2192

Fabbiano S, Menacho-Márquez M, Sevilla MA, Albarrán-Juárez J, Zheng Y, Offermanns S, Montero MJ, Bustelo XR. (2014) Genetic dissection of the Vav2-Rac1 signaling axis in vascular smooth muscle cells. Mol Cell Biol. 34, 4404-4419

Gao F, Chambon P, Offermanns S, Tellides G, Kong W, Zhang X, Li W. (2014) Disruption of TGF-beta signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm. Biochem. Biophys. Res. Commun. 454, 137-143

Herring BP, Hoggatt AM, Burlak C, Offermanns S. (2014) Previously differentiated medial vascular smooth muscle cells contribute to neointima formation following vascular injury. Vasc Cell. 6, 21

Hoffmann J, Ospelt M, Troidl C, Voss S, Liebetrau C, Kim WK, Rolf A, Wietelmann A, Braun T, Troidl K, Sadayappan S, Barefield D, Hamm C, Nef H, Möllmann H. (2014) Sham surgery and inter-individual heterogeneity are major determinants of monocyte subset kinetics in a mouse model of myocardial infarction. PLoS One. 9, e98456.

Lei XF, Kim-Kaneyama JR, Arita-Okubo S, Offermanns S, Itabe H, Miyazaki T, Miyazaki A. (2014) Identification of Hic-5 as a Novel Scaffold for the MKK4/p54 JNK Pathway in the Development of Abdominal Aortic Aneurysms. J. Am. Heart Assoc. 3, e000747

Li W, Li Q, Jiao Y, Qin L, Ali R, Zhou J, Ferruzzi J, Kim RW, Geirsson A, Dietz HC, Offermanns S, Humphrey JD, Tellides G. (2014) Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis. J Clin Invest. 124, 755-67

Offermanns S. (2014) Heating up the cutaneous flushing response. Arterioscler. Thromb. Vasc. Biol. 34, 1122-1123

Offermanns S. (2014) Free Fatty Acid (FFA) and Hydroxy Carboxylic Acid (HCA) Receptors. Annu Rev Pharmacol Toxicol. 54, 407-34

Preuß B, Tunaru S, Henes J, Offermanns S, Klein R. (2014) A novel luminescence-based method for the detection of functionally active antibodies to muscarinic acetylcholine receptors of the M3 type (mAchR3) in patients' sera. Clin Exp Immunol. 177, 179-89

Rahman M, Muhammad S, Khan MA, Chen H, Ridder DA, Müller-Fielitz H, Pokorná B, Vollbrandt T, Stölting I, Nadrowitz R, Okun JG, Offermanns S, Schwaninger M. (2014) The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages. Nat. Commun. 5, 3944

Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad PD, Manicassamy S, Munn DH, Lee JR, Offermanns S, Ganapathy V. (2014) Activation of gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity 40, 128-139

Sun H, Li G, Zhang W, Zhou Q, Yu Y, Shi Y, Offermanns S, Lu J, Zhou N. (2014) Niacin activates the PI3K/Akt cascade via PKC- and EGFR-transactivation-dependent pathways through hydroxyl-carboxylic acid receptor 2. PloS One 9, e112310

Undeutsch H, Löf C, Offermanns S, Kero J. (2014) A mouse model with tamoxifen-inducible thyrocyte-specific cre recombinase activity. Genesis 52, 333-40

Wong MS, Leisegang MS, Kruse C, Vogel J, Schürmann C, Dehne N, Weigert A, Herrmann E, Brüne B, Shah AM, Steinhilber D, Offermanns S, Carmeliet G, Badenhoop K, Schröder K, Brandes RP (2014) Vitamin D Promotes Vascular Regeneration. Circulation. 130, 976-986

Worzfeld T, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S. (2014) Genetic dissection of plexin signaling in vivo. Proc Natl Acad Sci U S A. 111, 2194-2199

Worzfeld T, Offermanns S. (2014) Semaphorins and plexins as therapeutic targets. Nat Rev Drug Discov. 13, 603-621

Zielonka M, Krishnan RK, Swiercz JM, Offermanns S. (2014) The IκB Kinase Complex Is Required for Plexin-B-Mediated Activation of RhoA. PLoS One. 9, e105661


Conzelmann M, Williams EA, Tunaru S, Randel N, Shahidi R, Asadulina A, Berger J, Offermanns S, Jékely G. (2013) Conserved MIP receptor-ligand pair regulates Platynereis larval settlement. Proc Natl Acad Sci U S A 110, 8224-9

Engelstoft MS, Park WM, Sakata I, Kristensen LV, Husted AS, Osborne-Lawrence S, Piper PK, Walker AK, Pedersen MH, Nøhr MK, Pan J, Sinz CJ, Carrington PE, Akiyama TE, Jones RM, Tang C, Ahmed K, Offermanns S, Egerod KL, Zigman JM, Schwartz TW. (2013) Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab. 2, 376-392

Gangadharan V, Selvaraj D, Kurejova M, Njoo C, Gritsch S, Skoricova D, Horstmann H, Offermanns S, Brown AJ, Kuner T, Tappe-Theodor A, Kuner R. (2013) A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signaling pathways in sensory nerves in vivo. Pain 154, 2801-2812

Hanson J, Ferreirós N, Pirotte B, Geisslinger G, Offermanns S. (2013) Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A4. Biochem Pharmacol 85, 1795-802

Herder C, Swiercz JM, Müller C, Peravali R, Quiring R, Offermanns S, Wittbrodt J, Loosli F. (2013) ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation. Development 140, 2787-97

Jiang M, Ku WY, Fu J, Offermanns S, Hsu W, Que J. (2013) Gpr177 regulates pulmonary vasculature development. Development 140: 3589-3594

Lübkemeier I, Requardt RP, Lin X, Sasse P, Andrié R, Schrickel JW, Chkourko H, Bukauskas FF, Kim JS, Frank M, Malan D, Zhang J, Wirth A, Dobrowolski R, Mohler PJ, Offermanns S, Fleischmann BK, Delmar M, Willecke K. (2013) Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels. Basic Res Cardiol. 108, 348

Marchesi C, Rehman A, Rautureau Y, Kasal DA, Briet M, Leibowitz A, Simeone SM, Ebrahimian T, Neves MF, Offermanns S, Gonzalez FJ, Paradis P, Schiffrin EL. (2013) Protective role of vascular smooth muscle cell PPARγ in angiotensin II-induced vascular disease. Cardiovasc Res 97, 562-570

Mitschke MM, Hoffmann LS, Gnad T, Scholz D, Kruithoff K, Mayer P, Haas B, Sassmann A, Pfeifer A, Kilic A. (2013) Increased cGMP promotes healthy expansion and browning of white adipose tissue. FASEB J. 27, 1621-1630

Nohr MK, Pedersen MH, Gille A, Egerod KL, Engelstoft MS, Husted AS, Sichlau RM, Grunddal KV, Seier Poulsen S, Han S, Jones RM, Offermanns S, Schwartz TW. (2013) GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes. Endocrinology 154, 3552-3564  

Novoyatleva T, Schymura Y, Janssen W, Strobl F, Swiercz JM, Patra C, Posern G, Wietelmann A, Zheng TS, Schermuly RT, Engel FB. (2013) Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction. Basic Res. Cardiol. 108, 325

Ock S, Ahn J, Lee SH, Kang H, Offermanns S, Ahn HY, Jo YS, Shong M, Cho BY, Jo D, Abel ED, Lee TJ, Park WJ, Lee IK, Kim J. (2013) IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter. FASEB J 27, 4899-908

Schumacher D, Strilic B, Sivaraj KK, Wettschureck N, Offermanns S. (2013) Platelet-derived nucleoides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. Cancer Cell 24, 130-137

Schumacher D, Strilic B, Sivaraj KK, Wettschureck N, Offermanns S. (2013) Response to Harper et al. Cancer Cell 24, 288

Sivaraj KK, Takefuji M, Schmidt I, Adams R, Offermanns S, Wettschureck N. (2013) G13 controls angiogenesis through regulation of VEGFR-2 expression. Dev Cell 25, 427-34

Sonne SR, Bhalla VK, Barman SA, White RE, Zhu S, Newman TM, Prasad PD, Smith SB, Offermanns S, Ganapathy V. (2013) Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth. Biochim Biophys Acta 1832, 1149-1158

Takefuji M Krüger M, Sivaraj KK, Kaibuchi K, Offermanns S, Wettschureck N. (2013) RhoGEF12 controls cardiac remodeling by integrating G-protein- and integrin-dependent signaling cascades. J Exp Med 210:665-73

Tonack S, Tang C, Offermanns S. (2013) Endogenous metabolites as ligands for G-coupled receptors modulating risk factors for metabolic and cardiovascular disease. Am. J. Physiol. Heart Cir. Physiol. 304, H501-513

Troidl C, Jung G, Troidl K, Hoffmann J, Mollmann H, Nef H, Schaper W, Hamm CW, Schmitz-Rixen T. (2013) The temporal and spatial distribution of macrophage subpopulations during arteriogenesis. Curr Vasc Pharmacol. 11, 5-12

Zandi-Nejad K, Takakura A, Jurewicz M, Chandraker AK, Offermanns S, Mount D, Abdi R. (2013) The role of HCA2 (GPR109A) in regulating macrophage function. FASEB J 27, 4366-74

Zippel N, Malik RA, Frömel T, Popp R, Bess E, Strilic B, Wettschureck N, Fleming I, Fisslthaler B. (2013) Transforming Growth Factor-β-Activated Kinase 1 Regulates Angiogenesis via AMP-Activated Protein Kinase-α1 and Redox Balance in Endothelial Cells. Arterioscler Thromb Vasc Biol. 33, 2792-9


Althoff TF, Albarrán Juárez J, Troidl K, Tang C, Wang S, Wirth A, Takefuji M, Wettschureck N, Offermanns S (2012) Procontractile G-protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling. J. Exp. Med. 209, 2277-90

Blad CC, Tang C, Offermanns S (2012) G protein-coupled receptors for energy metabolites as new therapeutic targets. Nat. Rev. Drug. Discov. 11, 601-619

Frank M, Wirth A, Andri Eacute RE, Segschneider S, Kreuzberg MM, Dobrowolski R, Seifert G, Offermanns S, Nickenig G, Willecke K, Schrickel JW (2012) Connexin45 Provides Optimal AV-Nodal Conduction in the Adult Mouse Heart. Circ. Res. 111, 1528-1538

Freissmuth M, Offermanns S, Böhm S (2012) Pharmakologie & Toxikologie: von den molekularen Grundlagen zur Pharmakologie. Springer Medizin, Verlag Heidelberg.

Gambhir D, Ananth S, Veeranan-Karmegam R, Elangovan S, Hester S, Jennings E, Offermanns S, Nussbaum JJ, Smith SB, Thangaraju M, Ganapathy V, Martin PM (2012) GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy. Invest Ophthalmol Vis Sci 53, 2208-2217

Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D (2012) PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha(12). Nat Cell Biol 14, 686-696

Greif DM, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-Horse K, Espinoza FH, Olson L, Offermanns S, Krasnow MA. (2012) Radial construction of an arterial wall. Dev. Cell 23, 482-493

Hanson J, Gille A, Offermanns S (2012) Role of HCA(2) (GPR109A) in nicotinic acid and fumaric acid ester-induced effects on the skin. Pharmacol. Ther. 136, 1-7

Offermanns S (2012) It Ain’t Over ‘til the Fat Lady Sings. Sci. Transl. Med. 4, 148fs130

Pleines I, Hagedorn I, Gupta S, May F, Chakarova L, van Hengel J, Offermanns S, Krohne G, Kleinschnitz C, Brakebusch C, Nieswandt B (2012) Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood 119, 1054-1063

Sun T, Krishnan R, Swiercz JM (2012) Grb2 mediates Semaphorin 4D-dependent RhoA inactivation. J Cell Sci 125, 3557-3567

Szardien S, Nef HM, Voss S, Troidl C, Liebetrau C, Hoffmann J, Rauch M, Mayer K, Kimmich K, Rolf A, Rixe J, Troidl K, Kojonazarov B, Schermuly RT, Kostin S, Elsasser A, Hamm CW, Mollmann H (2012) Regression of cardiac hypertrophy by granulocyte colony-stimulating factor-stimulated interleukin-1beta synthesis. Eur Heart J 33: 595-605

Takefuji M, Wirth A, Lukasova M, Takefuji S, Boettger T, Braun T, Althoff T, Offermanns S, Wettschureck N. (2012) A G13-Mediated Signaling Pathway is Required for Pressure Overload-Induced Cardiac Remodeling and Heart Failure. Circulation 126: 1972-82

Tappe-Theodor A, Constantin CE, Tegeder I, Lechner SG, Langeslag M, Lepcynzsky P, Wirotanseng RI, Kurejova M, Agarwal N, Nagy G, Todd A, Wettschureck N, Offermanns S, Kress M, Lewin GR, Kuner R (2012) Galpha(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization. Pain 153, 184-96

Troidl K, Schaper W (2012) Arteriogenesis versus angiogenesis in peripheral artery disease. Diabetes Metab Res Rev 28 Suppl 1, 27-29

Tunaru S, Althoff TF, Nusing RM, Diener M, Offermanns S (2012) Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Proc Natl Acad Sci U S A 109, 9179-9184

Weissmann N, Sydykov A, Kalwa H, Storch U, Fuchs B, Schnitzler MM, Brandes RP, Grimminger F, Meissner M, Freichel M, Offermanns S, Veit F, Pak O, Krause KH, Schermuly RT, Brewer AC, Schmidt HH, Seeger W, Shah AM, Gudermann T, Ghofrani HA, Dietrich A (2012) Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun 3, 649

Wirth A and Offermanns S. (2012). Chapter 85: G-protein-Coupled Receptors in Smooth Muscle. In: Muscle: Fundamental Biology and Mechanisms of Disease, Vol. 2. Eds.: Hill JA and Olson E N. Elsevier Inc. Academic Press London, pp. 1145-1153

Worzfeld T, Swiercz JM, Looso M, Straub BK, Sivaraj KK, Offermanns S (2012) ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis. J Clin Invest 122, 3296-2305

Zeeb M, Axnick J, Planas-Paz L, Hartmann T, Strilic B, Lammert E. (2012) Pharmacological manipulation of blood and lymphatic vascularization in ex vivo-cultured mouse embryos. Nat Protoc 7, 1970-1982


Adjobo-Hermans MJ, Goedhart J, van Weeren L, Nijmeijer S, Manders EM, Offermanns S, Gadella TW, Jr. (2011) Real-time visualization of heterotrimeric G protein Gq activation in living cells. BMC Biol 9, 32

Albinsson S, Skoura A, Yu J, Dilorenzo A, Fernandez-Hernando C, Offermanns S, Miano JM, Sessa WC (2011) Smooth Muscle miRNAs Are Critical for Post-Natal Regulation of Blood Pressure and Vascular Function. PLoS One 6, e18869

Blad CC, Ahmed K, Ijzerman AP, Offermanns S (2011) Biological and pharmacological roles of HCA receptors. Adv Pharmacol 62, 219-250

Bondke Persson A, Buschmann EE, Lindhorst R, Langhoff R, Schulte KL, Troidl K, Buschmann I (2011) Therapeutic arteriogenesis in peripheral arterial disease: Combining intervention and passive training / Therapeutische Arteriogenese bei Peripherer Arterieller Verschlußkrankheit: Kombination von interventioneller Therapie und passivem Training. VASA 40, 177-187

Hillmeister P, Gatzke N, Dulsner A, Bader M, Schadock I, Hoefer I, Hamann I, Infante-Duarte C, Jung G, Troidl K, Urban D, Stawowy P, Frentsch M, Li M, Nagorka S, Wang H, Shi Y, le Noble F, Buschmann I (2011) Arteriogenesis Is Modulated on Bradykinin Receptor Signaling. Circ Res. 109, 524-533

Lob HE, Vinh A, Li L, Blinder Y, Offermanns S, Harrison DG (2011) Role of vascular extracellular superoxide dismutase in hypertension. Hypertension 58, 232-239

Lukasova M, Malaval C, Gille A, Kero J, Offermanns S (2011a) Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J Clin Invest 121, 1163-1173

Lukasova M, Hanson J, Tunaru S, Offermanns S (2011b) Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potential. Trends Pharmacol Sci 32, 700-707

Nemenoff RA, Horita H, Ostriker AC, Furgeson SB, Simpson PA, Vanputten V, Crossno J, Offermanns S, Weiser-Evans MC (2011) SDF-1{alpha} Induction in Mature Smooth Muscle Cells by Inactivation of PTEN Is a Critical Mediator of Exacerbated Injury-Induced Neointima Formation. Arterioscler Thromb Vasc Biol. 31, 1300-1308

Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, Ijzerman AP (2011) International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B). Pharmacol Rev 63, 269-290

Ogata N, Shinoda Y, Wettschureck N, Offermanns S, Takeda S, Nakamura K, Segre GV, Chung UI, Kawaguchi H (2011) G{alpha}q Signal in Osteoblasts Is Inhibitory to the Osteoanabolic Action of Parathyroid Hormone. J Biol Chem 286, 13733-13740

Planas-Paz L, Strilic B, Goedecke A, Breier G, Fassler R, Lammert E (2011) Mechanoinduction of lymph vessel expansion. EMBO J 13, 788-804

Schierling W, Troidl K, Apfelbeck H, Troidl C, Kasprzak PM, Schaper W, Schmitz-Rixen T (2011) Cerebral Arteriogenesis is Enhanced by Pharmacological as Well as Fluid-Shear-Stress Activation of the Trpv4 Calcium Channel. Eur J Vasc Endovasc Surg 41, 589-596


Ahmed, K., Tunaru, S., Tang, C., Müller, M., Gille, A., Sassmann, A., Hanson, J., and Offermanns, S. (2010) An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Cell Metab. 11, 311-19

Albinsson S, Suarez Y, Skoura A, Offermanns, S, Miano JM, Sessa WC. (2010) miRNAs are necessary for vascular smooth muscle growth, differentiation and function. Arterioscler Thromb Vasc Biol 30, 1118-1126

Casazza A, Finisguerra V, Capparuccia L, Camperi A, Swiercz JM, Rizzolio S, Rolny C, Christensen C, Bertotti A, Sarotto I, Risio M, Trusolino L, Weitz J, Schneider M, Mazzone M, Comoglio PM, Tamagnone L (2010) Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice. J Clin Invest 120, 2684-2698

Coulon P, Kanyshkova T, Broicher T, Munsch T, Wettschureck N, Seidenbecher T, Meuth SG, Offermanns S, Pape HC, Budde T (2010) Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling. Front Cell Neurosci 4, 132

Groneberg D, König P, Wirth A, Offermanns S, Koesling D, Friebe A. (2010) Smooth Muscle-Specific Deletion of Nitric Oxide-Sensitive Guanylyl Cyclase Is Sufficient to Induce Hypertension in Mice. Circulation 121, 401-409

Guilluy C, Brégeon J, Toumaniantz G, Rolli-Derkinderen M, Retailleau K, Loufrani L, Henrion D, Scalbert E, Bril A, Torres RM, Offermanns S, Pacaud P, Loirand G. (2010) The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. Nat. Med. 16, 183-190

Hanson J, Gille A, Zwykiel S, Lukasova M, Clausen BE, Ahmed K, Tunaru S, Wirth A, Offermanns S. (2010) Keratinocytes express GPR109A and mediate epidermal effects of nicotinic acid and mono-Methyl fumarate via COX-2-dependent prostanoid formation J. Clin. Invest. 120, 2910-2919

Hirschberg A, Deng S, Korostylev A, Paldy E, Costa MR, Worzfeld T, Vodrazka P, Wizenmann A, Götz M, Offermanns S, Kuner R. (2010) Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesis. Mol Cell Biol. 30, 764-80

Hoyer DP, Gronke S, Frank KF, Addicks K, Wettschureck N, Offermanns S, Erdmann E and Reuter H (2010) Diabetes-related defects in sarcoplasmic Ca(2+) release are prevented by inactivation of Galpha (11) and Galpha (q) in murine cardiomyocytes. Mol Cell Biochem 341, 235-244

Hoyer DP, Korkmaz Y, Gronke S, Addicks K, Wettschureck N, Offermanns S, Reuter H (2010) Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein Galpha11. Cardiovasc Diabetol 9, 93

Offermanns S (2010) Thrombozytäre Signaltransduktion. In: Hämostaseologie, Pötzsch B, Madlener K (Eds.) 2nd ed., Springer-Verlag, pp 81-88

Offermanns S (2010) In vivo Functions of Heterotrimeric G Proteins. In: Handbook of Cell Signalling (Vol. 2) Bradshaw RA, Dennis EA (Eds.) 2nd ed., Elsevier Inc., pp 1621-1627

Offermanns S (2010) G-Protein functions identified using genetic mouse models. In: G Protein-Coupled Receptors: Structure, Signalling, and Physiology, Siehler S, Milligan Graeme (Eds.), Cambridge University Press, pp 125-144

Sassmann A, Gier B, Gröne HJ, Drews G, Offermanns S, Wettschureck N. (2010) The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion J. Clin. Invest. 120, 2184-2193

Sassmann A, Offermanns S & Wettschureck N. (2010). Tamoxifen-inducible Cre-mediated recombination in adipocytes. Genesis, 48(10), 618-625.

Sayed A, Schierling W, Troidl K, Rüding I, Nelson K, Apfelbeck H, Benli I, Schaper W, Schmitz-Rixen T. (2010) Exercise linked ton transient increase in expression and activity of cation channels in newly formed hind-limb collaterals. EJVES 40, 81-87

Singh N, Thangaraju M, Prasad PD, Martin PM, Lambert NA, Boettger T, Offermanns S & Ganapathy V. (2010) Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases. J Biol Chem 285, 27601-27608

Strilic B, Eglinger J, Krieg M, Zeeb M, Axnick J, Babal P, Muller DJ, Lammert E (2010) Electrostatic cell-surface repulsion initiates lumen formation in developing blood vessels. Curr Biol 20(22), 2003-2009

Szereszewski JM, Pampillo M, Ahow MR, Offermanns S, Bhattacharya M & Babwah AV. (2010) GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Galpha(q/11) and beta-arrestin-dependent manner. PLoS One 5, e12964

Troidl K*, Tribulova S*, Cai WJ, Eitenmüller I, Wustrack H, Schierling W, Troidl C, Schaper W. (2010) Effects of endogenous NO and of DETA NONOate in Arteriogenesis. J Cardiovasc Pharmacol 55(2), 153-60

Troidl C, Nef H, Voss S, Schilp A, Kostin S, Troidl K, Szardien S, Rolf A, Schmitz-Rixen T, Schaper W, Hamm CW, Elsasser A, Mollmann H (2010) Calcium-dependent signalling is essential during collateral growth in the pig hind limb-ischemia model. J Mol Cell Cardiol 49(1), 142-151

Turm H, Grisaru-Granvosky S, Maoz M, Offermanns S, Bar-Shavit R (2010) DVL as a scaffold protein capturing classical GPCRs. Commun Integr Biol 3, 495-498

Turm H, Maoz M, Katz V, Yin YJ, Offermanns S, Bar-Shavit R. (2010) Protease activated receptor1 (PAR1) acts via  a novel G{alpha}13-dishevelled axis to stabilize {beta}-catenin levels. J Biol Chem 285, 15137-15148

Wang L, Guo DC, Cao J, Gong L, Kamm KE, Regalado E, Li L, Shete S, He WQ, Zhu MS, Offermanns S, Gilchrist D, Elefteriades J, Stull JT & Milewicz DM. (2010) Mutations in myosin light chain kinase cause familial aortic dissections. Am J Hum Genet 87, 701-707

Wirth A. (2010) Rho kinase and hypertension. Biochim Biophys Acta. May 13 [epub article]

Zeeb M, Strilic B, Lammert E (2010) Resolving cell-cell junctions: lumen formation in blood vessels. Curr Opin Cell Biol 22(5), 626-632

Zielonka M, Xia J, Friedel RH, Offermanns S, Worzfeld T. (2010) A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system. Exp Cell Res. 316, 2477-2486


Ahmed K, Tunaru S, Langhans CD, Hanson J, Michalski CW, Kölker S, Jones PM, Okun JG, Offermanns S. (2009) Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis. J Biol Chem. 284, 21928-33

Ahmed K, Tunaru S, Offermanns S. (2009) GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors. Trends Pharmacol Sci. 30, 557-562

Gutkind JS, Offermanns S. (2009) A new G(q)-initiated MAPK signaling pathway in the heart. Dev. Cell  16, 163-164

Herroeder S, Reichardt P, Sassmann A, Zimmermann B, Jaeneke D, Hoeckner J, Hollmann MW, Fischer KD, Vogt S, Grosse R, Hogg N, Gunzer M, Offermanns S, Wettschureck N. (2009) Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility. Immunity 30, 708-720

Korhonen H, Fisslthaler B, Moers A, Wirth A, Habermehl D, Wieland T, Schütz G, Wettschureck N, Fleming I, Offermanns S. (2009) Anaphylactic shock depends on endothelial Gq/G11. J Exp Med, 206, 411-420

Plaisance EP, Lukasova M, Offermanns S, Zhang Y, Cao G, Judd RL. (2009) Niacin stimulates adiponectin secretion through the GPR109A receptor. Am J Physiol Endocrinol Metab.  296, E549-558

Schierling W*, Troidl K*, Troidl C, Schmitz-Rixen T, Schaper W, Eitenmüller IK. (2009) The Role of Angiogenic Growth Factors in Arteriogenesis. J Vasc Res 46(4), 365-374

Schierling W, Troidl K, Mueller C, Troidl C, Wustrack H, Bachmann G, Kasprzak PM, Schaper W, Schmitz-Rixen T. (2009) Increased intravascular flow rate triggers cerebral arteriogenesis. J Cereb Blood Flow Metab 29(4), 726-37

Sprossmann F, Pankert P, Sausbier U, Wirth A, Zhou XB, Madlung J, Zhao H, Bucurenciu I, Jakob A, Lamkemeyer T, Neuhuber W, Offermanns S, Shipston MJ, Korth M, Nordheim A, Ruth P, Sausbier M. (2009) Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder. FEBS J. 276, 1680-97

Swiercz JM, Worzfeld T, Offermanns S. (2009) Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex. Mol Cell Biol 29, 6321-34.

Troidl C*, Troidl K*, Schierling W, Cai WJ, Nef H, Möllmann H, Kostin S, Schimanski S, Hammer L, Elsässer A, Schmitz-Rixen T, Schaper W. (2009) Trpv4 induces collateral vessel growth during regeneration of the arterial circulation. J Cell Mol Med 13, 2613-21

Troidl C, Möllmann H, Nef H, Masseli F, Voss S, Szardien S, Willmer M, Rolf A, Rixe J, Troidl K, Kostin S, Hamm C, Elsässer A. (2009) Classically and alternatively activated macrophages contribute to tissue remodelling after myocardial infarction. J Cell Mol Med 13, 3485-96.

Troidl K, Rüding I, Cai WJ, Mücke Y, Grossekettler L, Piotrowska I, Schierling W, Volger OL, Horrevoets AJ, Schmitz-Rixen T, Schaper W, Troidl C. (2009) Actin-binding Rho activating protein (Abra) is essential for fluid shear stress-induced arteriogenesis. Arterioscler Thromb Vasc Biol 29, 2093-101

Vodrazka P, Korostylev A, Hirschberg A, Swiercz JM, Worzfeld T, Deng S, Fazzari P, Tamagnone L, Offermanns S, Kuner R. (2009) The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways. Eur J Neurosci 30, 1193-208

Worzfeld T and Offermanns S. (2009) G-Proteins. In: Schwab M. (ed). Encyclopedia of Cancer, 2nd edn. Springer, Berlin Heidelberg New York, 1189-1192 (ISBN: 978-3-540-47648-1)

Worzfeld T, Rauch P, Karram K, Trotter J, Kuner R, Offermanns S. (2009) Mice lacking Plexin-B3 display normal CNS morphology and behaviour. Mol Cell Neurosci 42, 372-81

Wustrack H, Schierling W, Troidl K, Troidl C, Schaper W, Schmitz-Rixen T. (2009) Stimulierung des Wachstums peripherer und zerebraler Kollateralarterien zur Erhöhung der intravasalen Flussrate im Tiermodell. Gefäßchirurgie 23, 24-30


Bodor ET & Offermanns S. (2008) Nicotinic acid: an old drug with a promising future. Br. J. Pharmacol. 153 (Suppl 1), S68-S75

Broicher T, Wettschureck N, Munsch T, Coulon P, Meuth SG, Kanyshkova T, Seidenbecher T, Offermanns S, Pape HC, Budde T. (2008) Muscarinic ACh receptor-mediated control of thalamic activity via Gq/G11-family G-proteins. Pflugers Arch 456, 1049-1060

Gille A, Bodor ET, Ahmed K, Offermanns S. (2008) Nicotinic acid: Pharmacological effects and mechanisms of action. Annu Rev Pharmacol Toxicol 48, 79-106

Korostylev A, Worzfeld T, Deng S, Friedel RH, Swiercz JM, Vodrazka P, Maier V, Hirschberg A, Ohoka Y, Inagaki S, Offermanns S, Kuner R. (2008) Plexin-B2, but not plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo. Development 135, 3333-3345

Moers A, Nürnberg A, Goebbels S, Wettschureck N, Offermanns S. (2008) Gα12/Gα13-deficiency causes localized overmigration of neurons in the developing cerebral and cerebellar cortices. Mol Cell Biol 28, 1480-1488

Ngai J, Methi T, Adressen KW, Levy FO, Trogersen KM, Vang T, Wettschureck N, Taskén K. (2008) The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway. Eur J Immunol 38, 3208-18.

Nürnberg A (2008): The roles of Gq and G12 families of G-proteins in the regulation of neurite morphology. Institute of Pharmacology. Submitted to the Medical Faculty of the Ruperto-Carola University of Heidelberg.
Nürnberg A, Bräuer AU, Wettschureck N, Offermanns S. (2008) Antagonistic regulation of neurite morphology through Gq/G11 and G12/G13. J Biol Chem 283, 35526-35531

Offermanns S, Rosenthal W. (2008) Encyclopedia of molecular pharmacology, 2nd edn. Berlin ; New York: Springer.

Sato T, Kawamura Y, Asai R, Amano T, Uchijima Y, Dettlaff-Swiercz DA, Offermanns S, Kurihara Y, Kurihara H. (2008) Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development. Development 135, 755-765

Swiercz JM, Worzfeld T, Offermanns S. (2008) ErbB-2 and Met Reciprocally Regulate Cellular Signaling via Plexin-B1. J Biol Chem 283, 1893-1901

Wirth A, Benyó Z, Lukasova M, Leutgeb B, Wettschureck N, Gorbey S, Őrsy P, Horváth B, Maser-Gluth C, Greiner E, Lemmer B, Schütz G, Gutkind S, Offermanns S. (2008) G12/G13-LARG-mediated signalling in vascular smooth muscle is required for salt-induced hypertension. Nat Med 14, 64-68

Wirth A, Offermanns S. (2008) G-protein mediated signalling in salt-dependent hypertension. Drug Discov Today Dis Mech 5, e307-314

Worzfeld T (2008) Plexins. In: Encyclopedia of Molecular Pharmacology, Offermanns, Stefan; Rosenthal, Walter (Eds.) 2nd ed., XXVII, 1505 p. 487 (ISBN: 978-3-540-38921-7)

Worzfeld, T, Wettschureck, N, Offermanns S. (2008) G(12)/G(13)-mediated signalling in mammalian physiology and disease. Trends Pharmacol. Sci. 29, 582-589


Ahmed K, Offermanns S. (2007) Nicotinic acid in lipid metabolism disorders. Pharm Unserer Zeit 36, 120-125

Deng S, Hirschberg A, Worzfeld T, Penachioni JY, Korostylev A, Swiercz JM, Vodrazka P, Mauti O, Stoeckli E, Tamagnone L, Offermanns S, Kuner R. (2007) Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo. J Neurosci 27, 6333-6347

Kero J, Ahmed K, Wettschureck N, Tunaru S, Wintermantel T, Greiner E, Schütz G, Offermanns S. (2007) Thyrocyte-specific Gq/G11-deficiency impairs thyroid function and prevents goiter development. J Clin Invest 117, 2399-2407

Müller MW, Giese NA, Swiercz JM, Ceyhan GO, Esposito I, Hinz U, Büchler P, Giese T, Büchler MW, Offermanns S, Friess H. (2007) Association of axon guidance factor Semaphorin 3A with poor outcome in pancreatic cancer. Int J Cancer 121, 2421-2433

Offermanns S (2007) Conditional mutagenesis of G-protein coupled receptors and G-proteins. In: Handb Exp Pharmacol 178, 491-509

Sassmann, A (2007):Charakterisierung der Stickstoffmonoxid-Synthase-Isoformen in kardiovaskulär relevanten Organen während der Entwicklung der spontanen Hypertonie bei Ratten. Universität zu Lübeck.

Tappe-Theodor A, Agarwal N, Katona I, Rubino T, Martini L, Swiercz J,Mackie K, Monyer H, Parolaro D, Whistler J, Kuner T, Kuner R. (2007) A molecular basis of analgesic tolerance to cannabinoids. J Neurosci 27(15), 4165-77

Wettschureck N, Lee E, Libutti SK, Offermanns S, Robey PG, Spiegel AM. (2007) Parathyroid-specific double knockout of Gq and G11 α-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+-sensing receptor. Mol Endocrinol 21, 274-280

Worzfeld T (2007): Expressions- und Funktionsanalyse der B-Plexine; Submitted to the Medical Faculty of the Ruperto-Carola University of Heidelberg.


Benyo Z, Gille A, Bennett CL, Clausen BE, Offermanns S. (2006) Nicotinic Acid-induced flushing is mediated by activation of epidermal langerhans cells. Mol Pharmacol 70, 1844-1849

Eitenmüller I, Volger O, Kluge A, Troidl K, Barancik M, Cai WJ, Heil M, Pipp F, Fischer S, Horrevoets AJ, Schmitz-Rixen T, Schaper W. (2006) The range of adaptation by collateral vessels after femoral artery occlusion. Circ Res 99(6), 656-62.

Offermanns S. (2006) The nicotinic acid receptor GPR109A (HM74A/PUMA-G) as a new therapeutic target. Trends Pharmacol Sci 27, 384-390

Offermanns S. (2006) Activation of platelet function through G-protein-coupled receptors. Circ Res 99, 1293 – 1304

Rieken S, Herroeder S, Sassmann A, Wallenwein B, Moers A, Offermanns S, Wettschureck N. (2006) Lysophospholipids control integrin dependent adhesion in splenic B cells through Gi and G12/G13 family G-proteins, but not through Gq/G11. J Biol Chem 281, 36985-36992

Rieken S, Sassmann A, Herroeder S, Wallenwein B, Moers A, Offermanns S, Wettschureck N. (2006) G12/G13 family G proteins regulate marginal zone B cell maturation, migration, and polarization. J Immunol 177, 2985-2993

Wettschureck N, van der Stelt M, Tsubokawa H, Krestel H, Moers A, Petrosino S, Schütz G, di Marzo V, Offermanns S. (2006) Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation. Mol Cell Biol 26, 5888-5894


Aktas B, Pozgajova M, Bergmeier W, Sunnarborg S, Offermanns S, Lee D, Wagner DD, Nieswandt B. (2005) Aspirin induces platelet receptor shedding via ADAM17 (TACE). J Biol Chem. 280, 39716-39722

Benyo Z, Gille A, Kero J, Csiky M, Suchankova MC, Nusing RM, Moers A, Pfeffer K, Offermanns S. (2005) GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J Clin Invest 115, 3634-3640

Dettlaff-Swiercz DA, Wettschureck N, Moers A, Huber K, Offermanns S. (2005) Characteristic defects in neural crest cell specific Gαq/Gα11- and Gα12/Gα13-deficient mice. Dev Biol 282, 174-182

Goulimari P, Kitzing TM, Knieling H, Brandt DT, Offermanns S, Grosse R. (2005) Gα12/13 is essential for directed cell migration and localized Rho-Dia1 function. J Biol Chem 280, 42242-42251

Soulet C, Hechler B, Gratacap MP, Plantavid M, Offermanns S, Gachet C, Payrastre BA. (2005) A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation. J Thromb Haemost 3, 2296-2306

Taggart AK, Kero J, Gan X, Cai TQ, Cheng K, Ippolito M, Ren N, Kaplan R, Wu K, Wu TJ, Jin L, Liaw C, Chen R, Richman J, Connolly D, Offermanns S, Wright SD, Waters MG. (2005) D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J Biol Chem 280, 26649-26652

Tunaru S, Lattig J, Kero J, Krause G, Offermanns S. (2005) Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G). Mol Pharmacol 68, 1271-1280

Wettschureck N, Moers A, Wallenwein B, Maser-Gluth C, Offermanns S. (2005) Loss of Gq/11-family G-proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice. Mol Cell Biol 25, 1942-1948

Wettschureck N, Offermanns S. (2005) Mammalian G-proteins and their cell type specific functions. Physiol Rev 85, 1159-1204

Wieland T, Wettschureck N, Offermanns S (2005) Study of G proteins in cardiovascular research. In: Practical Methods in Cardiovascular Research, Dhein S, Mohr F, Delmar M (Eds.) Springer-Verlag, pp 759-783Wettschureck N, Offermanns S. (2005) Mammalian G-proteins and their cell type specific functions. Physiol Rev 85, 1159-1204

Wieland T, Wettschureck N, Offermanns S (2005) Study of G proteins in cardiovascular research. In: Practical Methods in Cardiovascular Research, Dhein S, Mohr F, Delmar M (Eds.) Springer-Verlag, pp 759-783


Agarwal N, Offermanns S, Kuner R (2004) Conditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia. Genesis 38: 122-129

Grüner S, Prostredna M, Aktas B, Moers A, Schulte V, Krieg T, Offermanns S, Eckes B, Nieswandt B (2004) Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced a2b1 levels or concomitant aspirin therapy. Circulation 110: 2946-2951

Hartmann, J., Blum, R., Kovalchuk, Y., Adelsberger, H., Kuner, R., Durand, G.M., Miyata, M., Kano, M., Offermanns, S., and Konnerth, A. 2004. Distinct roles of Galpha(q) and Galpha11 for Purkinje cell signaling and motor behavior. J Neurosci 24:5119-5130..

Moers, A., Wettschureck, N., Gruner, S., Nieswandt, B., and Offermanns, S. 2004. Unresponsiveness of Platelets Lacking Both G{alpha}q and G{alpha}13: Implications for collagen-induced platelet activation. J Biol Chem 279:45354-45359.

Moers, A., Wettschureck, N., and Offermanns, S. 2004. G13-mediated signaling as a potential target for antiplatelet drugs. Drug News Perspect 17:493-498.

Nieswandt, B., and Offermanns, S. 2004. Pharmacology of platelet adhesion and aggregation. In Handbook of experimental Pharmacology. J. Behrens, and J. Nelson, editors. Berlin, Heidelberg, New York: Springer. 437-471.

Offermanns S (2004) Antiplatelet drugs. In: Encyclopedic Reference of Molecular Pharmacology, Offermanns S, Rosenthal W (Eds.), Springer-Verlag, pp 106-109 

Offermanns S (2004) G12/G13 family. In: Encyclopedia of Biological Chemistry Vol. 2, Lennarz WJ, Lane MD (Eds.), pp 158-161

Offermanns S (2004) G-Protein-Mediated Signalling Pathways. In: Handbook of Experimental Pharmacology Vol. 159,

Offermanns S, Hein L (Eds.), Springer-Verlag, pp 165-192

Offermanns S (2004) In vivo functions of heterotrimeric G-proteins. In: Handbook of Cell Signalling, Bradshaw RA, Dennis EA (Eds.), Academic Press, Vol. 2, pp 581-585

Swiercz, J.M., Kuner, R., and Offermanns, S. 2004. Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2. J Cell Biol 165:869-880.

Wettschureck, N., Moers, A., Hamalainen, T., Lemberger, T., Schutz, G., and Offermanns, S. 2004. Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice. Mol Cell Biol 24:8048-8054.

Wettschureck, N., Moers, A., and Offermanns, S. 2004. Mouse models to study G-protein-mediated signaling. Pharmacol Ther 101:75-89.

Worzfeld, T., Puschel, A.W., Offermanns, S., and Kuner, R. 2004. Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: an anatomical basis for morphogenetic effects of Sema4D during development. Eur J Neurosci 19:2622-2632.


Kuijpers, M.J., Schulte, V., Bergmeier, W., Lindhout, T., Brakebusch, C., Offermanns, S., Fassler, R., Heemskerk, J.W., and Nieswandt, B. 2003. Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo. Faseb J 17:685-687.

Marinissen, M.J., Servitja, J.M., Offermanns, S., Simon, M.I., and Gutkind, J.S. 2003. Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation. J Biol Chem 278:46814-46825.

Moers, A., Nieswandt, B., Massberg, S., Wettschureck, N., Gruner, S., Konrad, I., Schulte, V., Aktas, B., Gratacap, M.P., Simon, M.I., et al. 2003. G13 is an essential mediator of platelet activation in hemostasis and thrombosis. Nat Med 9:1418-1422.

Offermanns, S. 2003. G-proteins as transducers in transmembrane signalling. Prog Biophys Mol Biol 83:101-130.

Taggart, A.K., Kero, J., Gan, X., Cai, T.Q., Cheng, K., Ippolito, M., Ren, N., Kaplan, R., Wu, K., Wu, T.J., et al. 2005. (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J Biol Chem 280:26649-26652.

Tunaru, S., Kero, J., Schaub, A., Wufka, C., Blaukat, A., Pfeffer, K., and Offermanns, S. 2003. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat Med 9:352-355.

Vogt, S., Grosse, R., Schultz, G., and Offermanns, S. 2003. Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11. J Biol Chem 278:28743-28749.


Gu JL, Müller S, Mancino V, Offermanns S, Simon MI (2002) Interaction of Ga12 with Ga13 and Gaq signaling pathways. Proc Natl Acad Sci USA 99: 9352-9357

Krause M, Offermanns S, Stocker M, Pedarzani P (2002) Specific roles of Gaq and Ga11 in the cholinergic and glutamatergic modulation of potassium currents and excitability of hippocampal neurons. J Neurosci 22: 666-673

Kuner R, Swiercz J, Zywietz A, Tappe A, Offermanns S (2002) Characterization of the expression of PDZ-RhoGEF, LARG and Ga12/Ga13 proteins in the murine nervous system. Eur J Neurosci 16: 2333-2341

Miura M, Watanabe M, Offermanns S, Simon MI, Kano M (2002) Group I mGluR signalling via Gaq secures the induction of long-term potentiation in the hippocampal area CA1. J Neurosci 22: 8379-8390

Nieswandt B, Schulte V, Zywietz A, Gratacap MP, Offermanns S (2002) Costimulation of Gi- and G12/G13-mediated signaling pathways induces integrin aIIbb3 activation in platelets. J Biol Chem 277: 39493-39498

Swiercz J, Kuner R, Behrens J, Offermanns S (2002) Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron 35: 51-63

Wettschureck N, Offermanns S (2002) Physiological and pathological roles of the Rho/Rho-kinase mediated pathway. J Mol Med 80: 629-638


Gratacap MP, Payrastre B, Nieswandt B, Offermanns S (2001) Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Biol Chem 276: 47906-47913

Kleppisch T, Voigt V, Allmann R, Offermanns S (2001) Gaq-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region. J Neurosci 21: 4943-4948

Nieswandt B, Bergmeier W, Eckly A, Schulte V, Ohlmann P, Cazenave JP, Zirngibl H, Offermanns S, Gachet C (2001) Evidence for cross-talk between GPVI and Gi coupled receptors during collagen-induced platelet aggregation. Blood 97: 3829-3835

Offermanns S (2001) Der Gq/G11-vermittelte zellulärte Signalweg und seine Bedeutung für kardiale Erkrankungen. Z Kardiol 90: 601-606

Offermanns S (2001) G Proteins. In: Cancer Research Encyclopedia, Schwab, M. (Ed.), Springer-Verlag, pp 367-372

Offermanns S (2001) In vivo functions of heterotrimeric G-proteins: Studies in Ga-deficient mice. Oncogene 20: 1635-1642

Offermanns S, Negulescu P, Hu YH, Simon MI (2001) Conditionally expressed Ga15 couples to endogenous receptors in GH3 cells. Naunyn Schmiedeberg’s Arch Pharmacol 364: 140-148

Postma FR, Jalink K, Hengeveld T, Offermanns S, Moolenaar WH (2001) Ga13 mediates activation of a depolarizing chloride current that accompanies RhoA activation in both neuronal and non-neuronal cells. Curr Biol 11: 121-124

Wettschureck N, Rütten H, Zywietz A, Gehring D, Wilkie T, Chen J, Chien KR, Offermanns S (2001) Cardiomyocyte-restricted Gaq/Ga11-deficiency prevents pressure overload induced myocardial hypertrophy. Nat Med 7: 1236-1240

Zywietz A, Gohla A, Schmelz M, Schultz G, Offermanns S (2001) Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and -independent mechanisms. Involvement of Gq but not G11. J Biol Chem 276: 3840-3845


Blaukat A, Barac A, Cross MJ, Offermanns S, Dikic I (2000) G protein-coupled receptor-mediated MAP kinase activation through cooperation of Gaq and Gai signals. Mol Cell Biol 20: 6837-6848

Gohla A, Schultz G, Offermanns S (2000) A role for G12/G13 in agonist-induced vascular smooth muscle cell contraction. Circ Res 87: 221-227

Haley JE, Delmas P, Offermanns S, Abogadie FC, Simon MI, Buckley NJ, Brown DA (2000) Muscarinic inhibition of calcium current and M-current in Gaq-deficient mice. J Neurosci 20: 3973-3979

Hashimoto K, Watanabe M, Kurihara H, Offermanns S, Jiang H, Wu Y, Jun K, Shin HS, Inoue Y, Wu D, Simon MI, Kano M (2000) Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Gaq and phospholipase Cb4 Prog Brain Res 124: 31-48

Klemke M, Pasolli HA, Kehlenbach RH, Offermanns S, Schultz G, Huttner WB (2000) Characterization of XLas. II. Signal transduction properties. J Biol Chem 275: 33633-33640

Offermanns S (2000) Mammalian G-protein function in vivo: New insights through altered gene expression. Rev Physiol Biochem Pharmacol 140: 63-133

Offermanns S (2000) The role of heterotrimeric G-proteins in platelet activation. Biol Chem 381: 389-396

Ohlmann P, Eckly A, Freund M, Cazenave JP, Offermanns S, Gachet C (2000) Partial platelet aggregation without shape change and potentiation of collagen induced platelet aggregation by ADP in the absence of Gaq. Blood 96: 2134-213 

Ponimaskin E, Behn H, Adarichev V, Voyno-Yasenetskaya TA, Offermanns S, Schmidt MFG (2000) Acylation of Ga13 is important for its interaction with thrombin receptor, transforming activity and stress fiber formation. FEBS Lett 478: 173-177

Tsubokawa H, Offermanns S, Simon M, Kano M (2000) Calcium-dependent persistent facilitation of spike backpropagation in the CA1 pyramidal neurons. J Neurosci 20: 4878-4884